• 专利标题:   Composition suitable for biological applications used for producing filaments and producing article and implants, comprises thermoplastic bioresorbable polymer, carbon dot and optionally additive.
  • 专利号:   WO2022096391-A1
  • 发明人:   WINDHAB N, MONTERO MIRABET M, BENEDIKT A, ENGEL A, GOMES V, DAVE K, HASSAN M, NASRIN A, MAHMUD A Z
  • 专利权人:   EVONIK OPERATIONS GMBH
  • 国际专利分类:   A61F002/28, A61K009/00, A61L027/44, A61L027/52, A61L027/54, A61L027/56, A61L027/58, B33Y010/00, B33Y070/10
  • 专利详细信息:   WO2022096391-A1 12 May 2022 202246 Pages: 35 English
  • 申请详细信息:   WO2022096391-A1 WOEP080109 29 Oct 2021
  • 优先权号:   EP205326

▎ 摘  要

NOVELTY - Composition suitable for biological applications comprises at least one thermoplastic bioresorbable polymer; at least one carbon dot; and optionally at least one additive. USE - The composition is useful for producing filaments. The composition or the filament is useful for producing an article and implants (claimed). ADVANTAGE - The composition is suitable for biological applications, bio compatible and/or bio degradable and a composition of super hydrophile bioresorbable polymer composites for real time monitoring of scaffolds for tissue engineering, enhances cellular adhesion, growth, proliferation, differentiation and migration compared to commonly used compositions not including the at least one carbon dot, has desired superhydrophilic properties and improved performance and shows improved flowing properties which facilitated the enhanced processability of the compositions through the FDM to obtain acceptable print fidelity as well as enhanced stem cell proliferation. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a method for producing filaments of the composition involving melt blending the at least one thermoplastic polymer and the at least one carbon dot and optionally the at least one additive to obtain a mixture, preferably at 180-300 degrees C and melt extruding the obtained mixture, preferably at 180-250 degrees C to obtain the filaments; (2) the filament obtained by the method having a diameter of 1-2 mm; (3) a method for producing an article involving 3D printing, casting, injection molding or compression molding the composition or the filament to obtain the article, where the obtained article can be optionally further processed by laser cutting; (4) an article obtained by the method; and (5) a method for detecting the article involving irradiating a test object by UV, visible infrared (IR), and near IR and measuring via two-photon confocal microscopy the test object and obtaining a positive signal if the article is comprised.