• 专利标题:   Preparing sodium alginate-chitosan-graphene composite hydrogel useful in medicine cosmetic field for e.g. inhibiting growth of microorganisms, comprises e.g. preparing graphene oxide suspension, carrying out cross-linking reaction, carrying out dehydration and disinfection treatment and irradiating.
  • 专利号:   CN114605672-A
  • 发明人:   FU C, JU C, CAI H, WANG C, CHEN K, XIE T, XUE J
  • 专利权人:   HANGZHOU SIBINKE BIOTECHNOLOGY CO LTD, ZHEJIANG ZHONGDE LIFE HEALTH EDUCATION RES INST
  • 国际专利分类:   A61K047/04, A61K047/36, A61K009/48, A61L026/00, A61L027/08, A61L027/20, A61L027/50, A61L027/52, A61L027/54, A61L027/60, C08J003/075, C08J003/24, C08J003/28, C08K003/04, C08L005/04, C08L005/08
  • 专利详细信息:   CN114605672-A 10 Jun 2022 C08J-003/075 202274 Chinese
  • 申请详细信息:   CN114605672-A CN10379413 12 Apr 2022
  • 优先权号:   CN10379413

▎ 摘  要

NOVELTY - Preparing sodium alginate-chitosan-graphene composite hydrogel comprises (i) preparing graphene oxide suspension, (ii) preparing phosphate buffered saline, (iii) uniformly mixing sodium alginate and chitosan powder, (iv) adding and mixing graphene oxide suspension to sodium alginate and chitosan powder, adding phosphate buffered saline solution, and allowing to stand obtained reaction system, (v) heating and stirring reaction system to obtain hydrogel premix, (vi) preparing calcium salt solution, pouring out hydrogel premix solution and uniformly cover it on plate, and immersing in calcium salt solution to carry out cross-linking reaction, (vii) removing hydrogel, repeatedly washing, immersing in ethanol aqueous solution of increasing concentration to carry out dehydration and disinfection treatment, and (viii) irradiating hydrogel under an ultraviolet lamp to obtain sodium alginate-chitosan-graphene composite hydrogel. USE - The method is useful for preparing sodium alginate-chitosan-graphene composite hydrogel in medicine cosmetic field (claimed), and inhibiting growth of microorganisms, promoting cell adhesion, proliferation and differentiation. ADVANTAGE - The method: utilizes good protein adsorption function and mechanical enhancement function of graphene to solve technical defects of alginate hydrogel itself; utilizes natural polymer materials i.e. chitosan with low cost and wide sources, which solves problems of toxicity and environmental protection; promotes graphene dispersion in hydrogel and forms double network reinforced structure with sodium alginate, which improves mechanical properties and anti-cracking properties of hydrogel; and is simple. The hydrogel material has high mechanical properties.