• 专利标题:   Preparing biosensor used for detecting alpha-fetoprotein for diagnosing hepatic cancer, by synthesizing graphene functionalized with amino groups with anti-alpha-fetoprotein monoclonal antibody on surface of sensor with surface acoustic wave by direct transfer.
  • 专利号:   RO135947-A0
  • 发明人:   VOICU S I, PALLAPAPAVLU A, ANTONIAC V I, MICULESCU F, SEMENESCU A, COSTOIU M C, MATES I M, PRISECARU D A
  • 专利权人:   UNIV POLITEHNICA DIN BUCURESTI
  • 国际专利分类:   G01N027/327, G01N033/574
  • 专利详细信息:   RO135947-A0 30 Aug 2022 G01N-033/574 202280 Pages: 3 English
  • 申请详细信息:   RO135947-A0 RO000208 20 Apr 2022
  • 优先权号:   RO000208

▎ 摘  要

NOVELTY - Process for preparing biosensor involves synthesizing graphene functionalized with amino groups with anti-α -fetoprotein (AFP) monoclonal antibody and its controlled deposition on the surface of a sensor with surface acoustic waves (SAW) by performing direct transfer induced by krypton fluoride laser beam in UV at a fluence of 100 mJ/cm2of a thin pixel of graphene functionalized with anti-AFP antibody on golden electrodes. USE - The process is useful for preparing biosensor, which is used for detecting tumor marker i.e. AFP for diagnosing hepatic cancer. ADVANTAGE - The process prepares biosensor, which rapidly diagnoses hepatic cancer, determines small amounts of AFP in blood, and continuously monitors AFP concentrations.