▎ 摘　　要

NOVELTY - The method involves bringing a sample into contact with an electrochemical microsensor comprising an array of working microelectrodes. Thick film-coated microelectrodes with conductive additive incorporated into the coating are selected from a group consisting of polysaccharide-coated microelectrodes and platinum black-coated microelectrodes. Thin film-coated microelectrodes are selected from the group consisting of reduced graphene oxide-coated microelectrode and transition metal chalcogenide-coated microelectrodes. Raw data electrochemical signals are preprocessed. A chemometric method is applied to the preprocessed or raw data, to quantify clozapine in the sample. USE - Method for electrochemical detection of clozapine in a whole blood sample or plasma sample of a patient prescribed with antipsychotic drugs e.g. norepinephrine and uric acid. ADVANTAGE - The electrochemical microsensor has enhanced sensitivity towards redox active drugs such as clozapine and enables their detection even in small blood sample volumes. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of electrochemical detectability of clozapine in a blood sample using a single surface-modified electrode to generate an electrochemical signal indicative of clozapine concentration.