• 专利标题:   Sensor useful for detecting a prostate-specific biomarker, comprises a graphene layer deposited on an underlying substrate, antibodies coupled to the graphene layer to generate an antibody-functionalized graphene layer.
  • 专利号:   WO2022125501-A1, WO2022125501-A9, US2022196666-A1
  • 发明人:   ABEDI M, NAWANA N, TASLIM M E, FOTOUHI M, GREENFIELD E A
  • 专利权人:   GRAPHENEDX INC, GRAPHENEDX INC
  • 国际专利分类:   G01N033/543, G01N033/551, G01N033/574, G01N027/12
  • 专利详细信息:   WO2022125501-A1 16 Jun 2022 G01N-033/574 202262 Pages: 52 English
  • 申请详细信息:   WO2022125501-A1 WOUS062132 07 Dec 2021
  • 优先权号:   US122281P, US542400

▎ 摘  要

NOVELTY - Sensor for detecting a prostate-specific biomarker, comprises a graphene layer deposited on an underlying substrate, antibodies coupled to the graphene layer to generate an antibody-functionalized graphene layer, where the antibodies exhibit specific binding to a prostate specific biomarker, and electrical conductors electrically coupled to the antibody-functionalized graphene layer for measuring an electrical property. USE - The sensor is useful for detecting a prostate-specific biomarker (claimed). ADVANTAGE - The sensor: can be calibrated to allow the quantification of the detected prostate-specific biomarker; exhibit specific binding to the prostate-specific biomarker; and have high specificity. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) detecting a prostate-specific biomarker in a sample; and (2) a sensor for detecting a prostate-specific biomarker. DESCRIPTION OF DRAWING(S) - The figure shows the schematic representation of the sensor. Sensor (100) Sensing element (102) Antibodies and/or aptamers (104) Graphene layer (106) Underlying substrate (108)