• 专利标题:   Preparing graphene oxide-manganese tungstate-polyethylene glycol nano-composite material useful as nano-hybrid material for magnetic resonance imaging, comprises mixing the alcoholic solutions of bivalent manganese salt and graphene oxide.
  • 专利号:   CN106963951-A
  • 发明人:   WU H, ZHANG Y, CHANG X, ZONG L, LIU Y, YANG S
  • 专利权人:   UNIV SHANGHAI NORMAL
  • 国际专利分类:   A61K041/00, A61K049/04, A61K049/12, A61K049/18, A61P035/00
  • 专利详细信息:   CN106963951-A 21 Jul 2017 A61K-049/12 201769 Pages: 15 Chinese
  • 申请详细信息:   CN106963951-A CN10107627 27 Feb 2017
  • 优先权号:   CN10107627

▎ 摘  要

NOVELTY - Preparing graphene oxide-manganese tungstate-polyethylene glycol nano-composite material comprises: (i) mixing bivalent manganese salt alcohol solution and graphene oxide alcohol solution, adjusting its pH to 4-6 to obtain a mixed solution; (ii) dissolving tungstate in deionized water to obtain aqueous tungstate solution; and (iii) slowly adding aqueous tungstate solution into the mixed solution, then adding aminohexanoic acid, stirring, heating, then adding polyethylene glycol, reacting, cooling, centrifuging, washing, dispersing the solid product in deionized water, then sonicating. USE - The nano-composite material is useful as nano-hybrid material for magnetic resonance imaging, photoacoustic imaging, computed tomography imaging and photothermal treatment (claimed). DETAILED DESCRIPTION - Preparing graphene oxide-manganese tungstate-polyethylene glycol nano-composite material comprises: (i) respectively preparing bivalent manganese salt alcohol solution and graphene oxide alcohol solution, mixing the two solutions by stirring, adjusting its pH to 4-6 to obtain a mixed solution; (ii) dissolving tungstate in deionized water to obtain aqueous tungstate solution, where the molar ratio of manganese ion and tungstate ion is 1:1; and (iii) slowly adding aqueous tungstate solution into the mixed solution, then adding aminohexanoic acid, stirring, heating to 180-220 degrees C, then adding polyethylene glycol, continuously reacting for 3-5 hours, naturally cooling to room temperature, centrifuging, washing, dispersing the solid product in deionized water, then sonicating. An INDEPENDENT CLAIM is also included for graphene oxide-manganese tungstate-polyethylene glycol nano-composite material.