▎ 摘　　要

NOVELTY - System (100) comprises chip-based field effect biosensor (104) comprising sensing surface, a bead control device, a measurement controller and bead control device to perform calibration measurement of at least one of the output signals with a first set of the beads positioned within the measurement distance of the sensing surface. USE - The system is useful in transportation and for detecting analytes. ADVANTAGE - The system: utilizes chip-based field effect biosensors, with beads to capture target moieties and bead control components to position the beads near the sensing surface, which efficiently and inexpensively transport and detect analytes; and utilizes removal circuitry which allows the non-incubated beads to be removed from the sensing surface prior to sensing of incubated beads. DETAILED DESCRIPTION - System (100) comprises a chip-based field effect biosensor (104) comprising a sensing surface, configured so that at least one output signal for the chip-based field effect biosensor are affected by electrical charges within a measurement distance of the sensing surface, in response to application of at least one excitation condition to the chip-based field effect biosensor and application of a fluid in contact with the sensing surface, a bead control device comprising at least one bead control component for electromagnetically positioning many beads within the fluid, where the beads are functionalized with a capture moiety to bind to a target moiety, a measurement controller configured to operate the chip- based field effect biosensor and the bead control device to perform a calibration measurement of at least one of the output signals with a first set of the beads positioned within the measurement distance of the sensing surface, where the first set of the beads has not been incubated in a sample solution, remove the first set of the beads from the sensing surface and perform a detection measurement of the at least one output signal with a second set of the beads positioned within the measurement distance of the sensing surface, where the second set of the beads has been incubated in the sample solution and an analysis module configured to determine a parameter relating to presence of the target moiety in the sample solution, based on the calibration measurement and the detection measurement. INDEPENDENT CLAIMS are also included for: (1) providing many beads functionalized with a capture moiety to bind to a target moiety, positioning a first set of the beads within a fluid to be within a measurement distance of a sensing surface of a chip-based field effect biosensor, where the first set of the beads has not been incubated in a sample solution, performing a calibration measurement of at least one output signal from the chip-based field effect biosensor, removing the first set of the beads from the sensing surface, incubating a second set of the beads in the sample solution, positioning the second set of the beads within the fluid to be within the measurement distance of the sensing surface, performing a detection measurement of the output signal and determining a parameter relating to presence of the target moiety in the sample solution, based on the calibration measurement and the detection measurement; and (2) An apparatus comprising means for positioning many beads, within a fluid, within a measurement distance of a sensing surface of a chip-based field effect biosensor, means for performing a calibration measurement using the chip-based field effect biosensor, with a first set of the beads positioned within the measurement distance of the sensing surface, where the first set of the beads has not been incubated in a sample solution and means for performing a detection measurement using the chip-based field effect biosensor, with a second set of the beads positioned within the measurement distance of the sensing surface, where the second set of the beads has been incubated in the sample solution. DESCRIPTION OF DRAWING(S) - The figure shows the schematic view of the system. System (100) Chip-based field effect biosensor (104) Computing device (114) Remote data repository (118) Data network (120)