• 专利标题:   Graphene channel component used for producing transistor for biosensor, comprises film and virus receptor portion immobilized on film by linker portion comprising carbene compound.
  • 专利号:   WO2022225347-A1, KR2022145781-A
  • 发明人:   KWON O S, KIM K H, KIM J Y, PARK S J, SEO S E, AN J, HA S, KWONOSUK, KIM J, PARK S, SEONGEUN S, AHN J E, HA S Y
  • 专利权人:   KOREA RES INST BIOSCIENCE BIOTECHNOLOG
  • 国际专利分类:   G01N033/543, G01N033/569, H01L051/05, G01N033/551
  • 专利详细信息:   WO2022225347-A1 27 Oct 2022 G01N-033/569 202295 Pages: 45
  • 申请详细信息:   WO2022225347-A1 WOKR005722 21 Apr 2022
  • 优先权号:   KR052544

▎ 摘  要

NOVELTY - A graphene channel component comprises graphene film and a virus receptor portion immobilized on a graphene film by a linker portion comprising a carbene compound (I) or (II). USE - Graphene channel component used for producing transistor of biosensor (all claimed) for detecting various virus such as SARS-CoV-2 virus, SARS-CoV virus, MERS-CoV virus, (H1N1) influenza virus or their variants (all claimed). ADVANTAGE - The graphene channel component can protect against virus such as SARS-CoV virus, MERS-CoV virus, SARS-CoV-2 virus, H1N1 influenza virus, or their variants, detects with high selectivity, high sensitivity, high stability, and/or high accuracy even in the Universal Transport Medium(RTM: food and drug administration (FDA) cleared collection and transport system) reagent and within a short period of about 1 minute compared to them existing diagnostic method and real-time virus diagnosis, and provides sensor, which ensures rapid and accurate diagnosis of various virus. DETAILED DESCRIPTION - A graphene channel component comprises graphene film and a virus receptor portion immobilized on a graphene film by a linker portion comprising a carbene compound of formula (I) or (II). R , R , R , R =H, 1-20C alkyl, 3-20C cycloalkyl, 6-30C aryl or 2-30C heteroaryl (all optionally substituted with alkyl, cycloalkyl, aryl or heteroaryl); R , R , R -R =H, 1-20C alkyl, 3-20C cycloalkyl, 6-30C aryl, 2-30C heteroaryl or group of formula (i); or at least one R , R , R -R =group of formula (i); R +R +R +R =hydrocarbyl ring; n=6-30;and A=functional group containing N. (a) When two or more substituents adjacent to each other among R7-R10combine to form a hydrocarbyl ring, at least one of the H bonded to C forming the hydrocarbyl ring is substituted with the group (i). An INDEPENDENT CLAIM is included for a graphene transistor, which comprises a substrate, graphene channel component and a pair of electrodes.