• 专利标题:   Sensor for sequencing long-chain molecule, comprises electrodes, each electrode essentially comprises conductive layer and insulator layer, and microfluidic channel is configured to present the long-chain molecule to electrodes such that long-chain molecule is sequenced by measurements.
  • 专利号:   US2023097858-A1, WO2023056437-A1
  • 发明人:   SCHERER A
  • 专利权人:   CALIFORNIA INST OF TECHNOLOGY, CALIFORNIA INST OF TECHNOLOGY
  • 国际专利分类:   C12Q001/6869, G01N027/04, G01N027/22, B01L003/00, G01N027/327, G01N027/414
  • 专利详细信息:   US2023097858-A1 30 Mar 2023 G01N-027/04 202330 English
  • 申请详细信息:   US2023097858-A1 US937178 30 Sep 2022
  • 优先权号:   US250340P, US277033P, US937178

▎ 摘  要

NOVELTY - Sensor comprises electrodes, each electrode essentially comprises a conductive layer and an insulator layer, where conductive layer and insulator layer is less than 4 nm thick each. A microfluidic channel 410 is configured to present the long-chain molecule to electrodes such that the long-chain molecule is sequenced by measurements taken by one or more electrodes. USE - Sensor used in lateral sensor system for identifying the components of a long-chain molecule by making electrical measurements from fabricated nanoscale electrodes as molecule moves down narrow microfluidic channel and sequencing long-chain molecule. ADVANTAGE - The sensor helps in capacitance and conductivity (resistance) measurements, and microfluidic channel produce sensors that identify portions of long-chain molecules through electronic detection. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: Method of sequencing long-chain molecule, which involves: (1) passing the long-chain molecule through a microfluidic channel that is adjacent to a conductive layer of less than 4 nm thickness; (2) taking an electrical measurement from the conductive layer as the long-chain molecule passes the conductive layer; and (3) determining a component of the long-chain molecule from the electrical measurement; and Method of fabricating a sensor for sequencing long-chain molecule, which involves: (1) depositing one or more electrodes, each electrode essentially comprising conductive layer and insulator layer, conductive layer and insulator layer being less than 2 nm thick each; and (2) fabricating a microfluidic channel configured to present the long-chain molecule to the one or more electrodes such that the long-chain molecule can be sequenced by measurements taken by the one or more electrodes. DESCRIPTION OF DRAWING(S) - The drawing shows schematic view of a lateral sensor system. 410Microfluidic channel.