▎ 摘　　要

NOVELTY - Multi-component wound repairing hemostatic dressing based on polymeric amino acid is prepared by adding 15 pts. wt. polyglutamic acid into 300-400 pts. wt. solvent, maintaining the temperature at 20-40degrees Celsius, stirring for 10-20 minutes, adding 5-9 pts. wt. condensing agent and 7-10 pts. wt. N-hydroxyl succinimide, and stirring for 0.5-3 hours, adding 15-20 pts. wt. carboxymethyl chitosan and 20-25 pts. wt. octadecyl amine, raising the temperature to 45-75degrees Celsius and stirring and reacting for 6-24 hours, dialyzing for 24-72 hours with dialysis bag with a molecular weight of 3500, freeze-drying to obtain gel freeze-dry powder, dissolving the frozen powder obtained gel in 900-1000 pts. wt. deionized water, raising temperature to 20 to 40degrees Celsius, stirring and dispersing for 10 to 30 minutes, adding 0.5 to 2 parts of graphene oxide, stirring for 5 to 15 minutes, adding the polyglutamic acid cross-linked modified carboxymethyl chitosan obtained. USE - The multi-component wound repairing hemostatic dressing used for preventing various diseases of human body, which is directly related to the life health of human. No biological data given. ADVANTAGE - The multi-component wound repairing hemostatic dressing uses polyglutamic acid to modify the structure of carboxymethyl chitosan. The hydrophobic alkyl in the octadecyl amine can make the material become amphiphilic structure, with better affinity with the skin, at the same time, the amphiphilicity structure can obviously increase the subsequent added graphene oxide, the loading rate of the hydrophilic compound such as berberine and tea polyphenol. DETAILED DESCRIPTION - Multi-component wound repairing hemostatic dressing based on polymeric amino acid is prepared by adding 15 pts. wt. polyglutamic acid into 300-400 pts. wt. solvent, maintaining the temperature at 20-40degrees Celsius, stirring for 10-20 minutes, adding 5-9 pts. wt. condensing agent and 7-10 pts. wt. N-hydroxyl succinimide, and stirring for 0.5-3 hours, adding 15-20 pts. wt. carboxymethyl chitosan and 20-25 pts. wt. octadecyl amine, raising the temperature to 45-75degrees Celsius and stirring and reacting for 6-24 hours, dialyzing for 24-72 hours with dialysis bag with a molecular weight of 3500, freeze-drying to obtain gel freeze-dry powder, dissolving the frozen powder obtained gel in 900-1000 pts. wt. deionized water, raising temperature to 20 to 40degrees Celsius, stirring and dispersing for 10 to 30 minutes, adding 0.5 to 2 parts of graphene oxide, stirring for 5 to 15 minutes, adding the polyglutamic acid cross-linked modified carboxymethyl chitosan obtained , raising the temperature to 45-55degrees Celsius, adding 1 -2 pts. wt. acetic acid, stirring for 3 -6 hours, dialyzing for 24-72 hours with dialysis bag with molecular weight of 3500, freeze-drying, obtaining the gel freeze-dried powder; (3) dissolving the frozen powder obtained gel in 900-1000 portions of de-ionized water, raising the temperature to 20 to 40degrees Celsius, adding 0.5 to 2 pts. wt. of berberine hydrochloride and 0.2 to 1pts. wt. of tea polyphenol, ultrasonic for 30 to 60 minutes, stirring for 12 to 48 hours, adding 4 to 6 pts. wt. of collagen, stirring for 4 to 10 hours, freeze-drying to obtain multi-component wound repairing hemostatic dressing based on polymeric amino acid. DESCRIPTION OF DRAWING(S) - The drawing obtained by Example 4 based on multi-component wound surface repairing hemostasis dressing of the polymeric amino acid test result graph. (Drawing includes non-English language text). Comparative example (3) Experimental group od value/blank group od value (100)