▎ 摘　　要

NOVELTY - A strain sensor comprises a graphene layer, a metallic layer on the graphene layer, and a polymer on the graphene layer and the metallic layer. A piezoresistance of the strain sensor allows strain spanning four orders of magnitude to be detected. USE - Strain sensor is used as surface-enhanced Raman scattering (SERS) substrates for evaluating local chemical environments by Raman spectroscopy, measuring mechanical movements in a biological sample and conveying physiological information such as heart rate, pulse pressure, muscle movements and breathing, contractions of cells e.g. cardiomyocytes, and monitoring structural health. Can also be used as wearable sensors for skin or clothing, instrumented prostheses and nano-island sensor. The biological sample includes organ and biological cells including cardiomyocytes, neurons, muscle cells, and epidermal cells. ADVANTAGE - The strain sensor has improved biocompatibility, sensitivity such as gauge factor of 700 at 1% strain and cyclability, and suppressed crack propagation.