• 专利标题:   Graphene oxide-modified cetuximab composition useful in preparation of medicament for treating glioma, comprises cetuximab and graphene oxide.
  • 专利号:   CN106474483-A
  • 发明人:   LIU Z, LUO C, YANG K, LI C, ZENG Y, CHEN X, WANG X, HUANG Z, GONG X, LI Z
  • 专利权人:   UNIV CENT SOUTH XIANGYA HOSPITAL
  • 国际专利分类:   A61K039/395, A61K047/52, A61P035/00
  • 专利详细信息:   CN106474483-A 08 Mar 2017 A61K-047/52 201729 Pages: 12 Chinese
  • 申请详细信息:   CN106474483-A CN11203531 23 Dec 2016
  • 优先权号:   CN11203531

▎ 摘  要

NOVELTY - Graphene oxide-modified cetuximab composition comprises cetuximab and graphene oxide. The cetuximab and graphene oxide are linked by non-covalent bonding. The graphene oxide has particle size of less than 0.22 m. USE - The graphene oxide-modified cetuximab composition is useful in preparation of medicament for treating glioma (all claimed). DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for producing graphene oxide-modified cetuximab composition, which involves adding cetuximab and graphene oxide to solution comprising 50% phosphate buffer, and shaking the mixture at 4-40 degrees C for 2-24 hours.