▎ 摘　　要

NOVELTY - Preparing repairable skin gel dressing involves: (S1) dissolving collagen in glacial acetic acid solution to obtain a solution (A); (S2) adding metallothionein and recombinant human epidermal growth factor to the solution (A), and dissolving; (S3) dissolving graphene oxide in deionized water to obtain a graphene oxide suspension, and oscillating to obtain a microparticle liquid sol (B); (S4) mixing solution (A) and sol (B), ultrasonically processing, and cooling to obtain a colloidal mixed solution (C); (S5) freezing solution (C) in a mold to obtain a single-layer collagen-graphene oxide film; (S6) preparing a solution (D) using sodium pyrrolidone carboxylate, copper pyrrolidone carboxylate, allantoin and sea buckthorn seed oil; (S7) immersing the film in the solution (D); (S8) sticking the film on a silk layer; (S9) covering a pearlescent layer on the film to form a dressing layer; and (S10) adding the dressing layer to a packaging bag, flushing, and encapsulating. USE - The method is useful for preparing repairable skin gel dressing. ADVANTAGE - The method provides repairable skin gel dressing, which is conducive to the recovery of the skin, when tearing and applying the pearlescent layer to the affected area. DETAILED DESCRIPTION - Preparing repairable skin gel dressing involves: (S1) dissolving a preset mass of collagen in 0.05 M glacial acetic acid solution, placing in a water bath under ultrasonic vibration for 60 minutes to obtain a solution (A) with a collagen mass-to-volume ratio of 0.2-5%; (S2) adding 0.006-0.1 g metallothionein and 0.002-0.02 g recombinant human epidermal growth factor to the solution (A), dissolving under stirring, then adding 0.02-5 g proanthocyanidin, and thoroughly stirring; (S3) dissolving a preset mass of graphene oxide in deionized water at a mass-to-volume ratio of 0.02-8% to obtain a graphene oxide suspension, placing the suspension in an ultrasonic oscillator, placing in an ice water bath with 70-90% energy, and oscillating for 0.5-1.5 hours until the graphene oxide becomes a microparticle liquid sol (B); (S4) mixing the solution (A) and the sol (B) in a volume ratio of 5:1, ultrasonically processing the mixture for 20-40 minutes in an ice-water bath until the mixture becomes a homogeneous mixture, and cooling in a refrigerator at 4degrees Celsius for 12 hours until it becomes a colloidal mixed solution (C); (S5) placing the mixed solution (C) in a 0.5 mm mold, and freezing at -20degrees Celsius for 12 hours to obtain a single-layer collagen-graphene oxide film; (S6) dissolving 30-70 g sodium pyrrolidone carboxylate and 10-60 g copper pyrrolidone carboxylate in deionized water under stirring, then adding 0.02-5 g allantoin and 0.04-6 g sea buckthorn seed oil, and continuously stirring to dissolve to obtain a solution (D); (S7) immersing the single-layer collagen-graphene oxide film in the solution (D) for 1-2 hours; (S8) sticking the single-layer collagen-graphene oxide film on a silk layer as a base layer; (S9) covering a pearlescent layer on the collagen-graphene oxide film to form a dressing layer; and (S10) adding the dressing layer to a packaging bag, flushing with nitrogen protective gas, and encapsulating.