• 专利标题:   Electrochemical sensor used to detects the amount of glucose in liquid samples, includes an insulating support layer used as the top layer coating in the sensor and increasing the durability of the sensor surface.
  • 专利号:   WO2021112802-A1, TR202007785-A2
  • 发明人:   UYGUN Z O
  • 专利权人:   UNIV EGE
  • 国际专利分类:   A61B005/0245, G01N033/66
  • 专利详细信息:   WO2021112802-A1 10 Jun 2021 G01N-033/66 202154 Pages: 21 English
  • 申请详细信息:   WO2021112802-A1 WOTR051199 01 Dec 2020
  • 优先权号:   TR019281, TR007785

▎ 摘  要

NOVELTY - Electrochemical sensor includes an insulating support layer (1) used as the top layer coating in the sensor and increasing the durability of the sensor surface. A plastic insulating layer (2) containing the electrodes. A gold electrode (4), which interacts electrically with the platinum electrode (6) through the graphene connection layer (5). A graphene connection layer which is located on the plastic insulating layer between the gold and platinum electrodes and conducts the electric current between these two electrodes. A platinum electrode, which interacts electrically with the gold electrode through the graphene connection layer. The molecular glucose imprinted polymer layer (7) specific to glucose, which is the analyte desired to be determined, placed on the graphene connection layer. A sample chamber (8), which can receive at least 50 microliter of sample, which is defined to bring the sample in which the sugar amount is to be determined to contact the sensor. USE - Electrochemical sensor used to detects the amount of glucose in liquid samples (Claimed). ADVANTAGE - The electrochemical sensor are more advantageous than catalytic ones in that they do not require any additional molecules other than the receptor-ligand pairs given. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of determining the glucose amount in liquid samples of the sensor, which involves: (A) dripping the liquid samples whose sugar amount is desired to be determined into the sample chamber; (B) applying a maximum potential of 200 mV to the sensor with a frequency in the range of 100-150 hertz; (C) binding of glucose in the liquid sample to the glucose selective molecularly imprinted polymer (MIP) cavities on the graphene layer, and glucose bound to glucose selective MIP cavities on the graphene layer increases impedance and decreases capacitance; and (D) converting the rate of increase in impedance to ratio of glucose, confirming the selectivity of glucose by showing a decrease in the decrease in capacitance due to glucose binding. DESCRIPTION OF DRAWING(S) - The drawing shows the schematic side view of electrochemical sensor. Insulating support layer (1) Plastic insulating layer (2) Gold electrode (4) Graphene connection layer (5) Platinum electrode (6) Molecular glucose imprinted polymer layer (7) Sample chamber (8)