▎ 摘　　要

NOVELTY - Pyrocatechol-functionalized polypeptide (A) are new. USE - (A) is useful in ultra-low concentration single-component polypeptide hydrogel for preparing wound hemostatic agents, sealants and wound auxiliary materials, and in preparing hybrid polypeptide hydrogel (all claimed). ADVANTAGE - The ultra-low concentration single-component polypeptide hydrogel: has ultra-low critical gel-forming concentration, heat, salt and urea stability, tissue interface clearance, and excellent biocompatibility and biodegradability, which can quickly and efficiently stop bleeding and promote wound healing. The method of single-component polypeptide hydrogel: has simple and convenient process, and low production cost. DETAILED DESCRIPTION - Pyrocatechol-functionalized polypeptide (A) of formulae (I-III) are new. R = pyrocatechol moiety of formula (IV); x = 0, 1 or 2; and n, m = positive integers. INDEPENDENT CLAIMS are also included for: preparing ultra-low concentration single-component polypeptide hydrogel, comprising (i) taking carboxylated polypeptide as polymer backbone, and modifying by pyrocatechol to obtain pyrocatechol-functionalized polypeptide, (ii) oxidizing obtained pyrocatechol-functionalized polypeptide in alkali solution, and then dialyzing using deionized water, or stirring to obtain pyrocatechol-functionalized polypeptide solution, (iii) freezing the obtained solution, and thawing to obtain final product, (or) freeze-drying the obtained solution to obtain solid after freezing treatment, and then dissolving in phosphate buffer to obtain final product; hybrid polypeptide hydrogel. The hydrogel is obtained by mixing graphene oxide in ultra-low concentration single-component polypeptide hydrogel; and preparing hybrid polypeptide hydrogel, comprising (a) taking carboxylated polypeptide as polymer backbone, and modifying by pyrocatechol to obtain pyrocatechol-functionalized polypeptide, (b) oxidizing obtained pyrocatechol-functionalized polypeptide in alkali solution, then dialyzing using deionized water, or stirring to obtain pyrocatechol-functionalized polypeptide solution, and (c) freeze-drying the obtained solution to obtain solid after freezing treatment, then adding graphene oxide solution after dissolving in phosphate buffer to obtain hybrid polypeptide hydrogel blended with graphene oxide. (1) ultra-low concentration single-component polypeptide hydrogel, comprising (A) as core component, and the concentration of (A) is 0.1-1%, preferably greater than or equal to 0.4%;