▎ 摘　　要

NOVELTY - Detecting aminoglycoside antibiotics residue in milk by pre-processing comprises e.g. (i) synthesizing 3-glycidyloxypropyl)trimethoxysilane (GLYMO) and aminophenylboronic acid (APB), mixing GLYMO and APB, (ii) synthesizing mesoporous magnetic graphene composite material, (iii) synthesizing boronic acid modified mesoporous magnetic graphene composites, (iv) extracting the enrichment of aminoglycoside antibiotics in milk: adding modified mesoporous magnetic graphene composite material to matrix of milk protein and fat, mixing, collecting material, eluting the target molecule, and filtering. USE - The method is useful for detecting aminoglycoside antibiotics residue in milk by pre-processing (claimed). ADVANTAGE - The method: enriches antibiotics in milk; is time saving; and overcomes the severe matrix interference problem. DETAILED DESCRIPTION - Detecting aminoglycoside antibiotics residue in milk by pre-processing comprises (i) synthesizing 3-glycidyloxypropyl)trimethoxysilane (GLYMO) and aminophenylboronic acid (APB), mixing GLYMO and APB at low temperature, and raising the temperature for reacting, (ii) synthesizing mesoporous magnetic graphene composite material: uniformly dispersing the graphene in concentrated nitric acid for acidification to obtain graphene surface modified to ferroferric oxide micro-magnetic graphene by reaction, and coating on the mesoporous silicon, (iii) synthesizing boronic acid modified mesoporous magnetic graphene composites: adding mesoporous magnetic graphene composite material into GLYMO-APB solution, raising temperature, and allowing to react to finish the boric acid material modification, (iv) extracting the enrichment of aminoglycoside antibiotics in milk: adding mesoporous magnetic graphene composite material modified by boric acid to the matrix of milk protein and fat, mixing to allow the target molecule to enter the inner wall of the material passage and combine with a boronic acid group, collecting material for binding the target molecule, adding eluent to elute the target molecule into the material collecting in the magnetic field, and filtering the eluent directly for chromatographic detection.