• 专利标题:   Graphene-enhanced hydrogel used for preparing bacteria, drugs or gene carriers, and in medicament for treating chronic diarrhea, comprises amphiphilic graphene, sodium lactate, calcium alginate, and water.
  • 专利号:   CN113171464-A, CN113171464-B
  • 发明人:   LIU Z, WANG J, ZHANG Y, LI Y, JIAO Y, CAO J, QI X, ZHANG Q
  • 专利权人:   UNIV SOOCHOW
  • 国际专利分类:   A61K031/12, A61K035/74, A61K035/744, A61K035/747, A61K047/04, A61K047/12, A61K047/32, A61K047/34, A61K047/36, A61K009/06, A61P001/00, A61P001/12, A61P025/24, B01J013/00, C01B032/194
  • 专利详细信息:   CN113171464-A 27 Jul 2021 A61K-047/36 202175 Pages: 17 Chinese
  • 申请详细信息:   CN113171464-A CN10416280 19 Apr 2021
  • 优先权号:   CN10416280

▎ 摘  要

NOVELTY - Graphene-enhanced hydrogel comprises 0.1-5 %mass amphiphilic graphene, 0.25-3 %mass sodium lactate, 0.5-5 %mass calcium alginate, and remaining of water. USE - Graphene-enhanced hydrogel used for preparing bacteria, drugs or gene carriers, and in medicament for treating chronic diarrhea, depression or radiation intestinal injury (all claimed). ADVANTAGE - The graphene-enhanced hydrogel has excellent biocompatibility, has excellent mechanical properties and water retention stability and hinder oxygen permeability, extends the in vitro storage time of anaerobic bacteria, and used as a carrier for bacterial drugs, and effectively expands the application range of hydrogels. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a method for preparing graphene-enhanced hydrogel comprising adding amphiphilic graphene to sodium alginate solution, and adding calcium lactate solution to obtain graphene-enhanced hydrogel; and (2) a graphene-enhanced hydrogel bacterial carrier comprising the graphene-enhanced and bacteria, where the bacteria are loaded in the graphene-enhanced hydrogel.