▎ 摘　　要

NOVELTY - Connection complex is Cnp. The Cnp is a response substrate peptide fragment connected to a carbon chain whose number is n. The carbon chain can be embedded between the layers of cell membrane phospholipid molecules. The response substrate peptide fragment is amino acid sequence of the response substrate peptide fragment having 10 amino acids (SEQ ID NO: not defined), protein having more than 80% identity and the same function, preferably, the carbon chain is embedded in the cell membrane phospholipid molecular layer and relies on hydrophobic force and n is 18. The substrate peptide fragments are enzymatically hydrolyzed. The enzymolysis is metalloprotease, more preferably, the metalloprotease is metalloprotease-9. USE - Connection complex for preparing targeted monocyte connectors and monocyte targeted delivery systems, cell modification compound for preparing monocyte targeted delivery system, tumor targeting therapy cell for preparing monocyte targeted delivery system and monocyte target delivery MicroRNA155 treatment system (claimed). ADVANTAGE - The connection complex has good homing ability and induces the polarization of M2 macrophages to M1, provides ideas for cell surface engineering technology and cell gene technology, and method is simple, low in cost, easy to operate and control, and its cross-linking method is applied to the synthesis of various other systems. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a cell modification complex for tumor targeting therapy, which is a Cnp-GQDs-delivery target, and the GQDs are graphene quantum dots; (2) a tumor-targeted therapy cell, where targeted cell surface is modified with the cell modification compound, Cn is embedded in the cell membrane phospholipid molecular layer, preferably, the target cells are monocytes, more preferably, the monocytes are RAW264.7 monocyte-macrophages; (3) a method for constructing a cell modification complex, which involves using one end of the crosslinker sulfo-LC-SPDP to undergoe NHS ester reaction with the aminated GQDs, and the other end undergoes a maleimide chemical reaction with the sulfhydrylated miRNA155; (4) a method for constructing tumor-targeted therapy cells, which involves co-incubating the cell modification complex with the cells to be modified to obtain M-C18p-GQDs-miRNA155, the M being the cells to be modified, preferably, the cells to be modified are monocytes, more preferably, the monocytes are RAW264.7 mononuclear macrophages, preferably, the co-incubation condition is 36 h, and the cell density is 105; and (5) a composition, which comprises linking complex, the cell modifying complex and other elements for constructing tumor-targeted therapy cells.