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  • 专利标题:   Activating toll-like receptor (TLR) in cell used for inducing autophagy in cell, involves contacting cell with graphene oxide to activate TLR-2, TLR-4, TLR-7 and TLR-9 in cell.
  • 专利号:   US2015157659-A1, US9421224-B2
  • 发明人:   HU Y, CHEN G, TUAN H
  • 专利权人:   UNIV NAT TSINGHUA
  • 国际专利分类:   A61K033/00, A61K031/194, A61K009/00, A61K009/14
  • 专利详细信息:   US2015157659-A1 11 Jun 2015 A61K-033/00 201544 Pages: 22 English
  • 申请详细信息:   US2015157659-A1 US622457 13 Feb 2015
  • 优先权号:   US913716, US622457

▎ 摘　　要

NOVELTY - Method for activating toll-like receptor (TLR) in a cell involves contacting the cell with graphene oxide to activate at least one of TLR-2, TLR-4, TLR-7 and TLR-9 in the cell, where at least one of TLR-2, TLR-4, TLR-7 and TLR-9 are activated in the cell. USE - The method is useful for activating TLR in a cell, preferably immune cell (all claimed) for inducing autophagy in a cell. ADVANTAGE - The method enables to activate TLR in a cell without revealing apparent apoptosis after treatment of the graphene oxide.