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  • 专利标题:   Graphene-catalysts conjugate used to e.g. make biomedical device e.g. implant and biosensor, comprises graphene support, and first and second catalysts conjugated to the support, where the second catalyst is different from first catalyst.
  • 专利号:   WO2015113056-A1, US2016339154-A1
  • 发明人:   DUAN X, HUANG Y, XUE T, MEYERHOFF M E
  • 专利权人:   UNIV CALIFORNIA, UNIV MICHIGAN
  • 国际专利分类:   A61L027/50, A61L029/14, B01J021/18, B01J031/16, A61L027/30, A61L027/54, A61L031/08, A61L031/16, A61L033/00, A61L033/02, B01J031/00, B01J031/18, C12N011/14
  • 专利详细信息:   WO2015113056-A1 30 Jul 2015 B01J-031/16 201554 Pages: 35 English
  • 申请详细信息:   WO2015113056-A1 WOUS013118 27 Jan 2015
  • 优先权号:   US932091P, US15113940

▎ 摘　　要

NOVELTY - Graphene-catalysts conjugate comprises a graphene support, a first catalyst conjugated to the graphene support, and a second catalyst conjugated to the graphene support and is different from the first catalyst. USE - The graphene-catalysts conjugate is useful for: making a biocompatible film; making the biomedical device which is an implant, a catheter, a vascular graft, a biosensor, or a heart valve; improving the antithrombotic property of an implant (all claimed); and producing nitroxyl. ADVANTAGE - The graphene-catalysts conjugate: allows graphene to functions as a support to integrate molecular catalyst hemin and enzymatic catalyst glucose oxidase with retained functionality for biomimetic generation of antithrombotic species, and thus the conjugate acts as a tandem catalyst; provides a long-lasting antithrombotic coating for blood contacting biomedical devices; provides the biocompatible polymer film which exhibits enhanced anti-platelet activity due to the continuous generation of nitroxyl; and maintains good and stable activity over an extended period, and excellent recyclability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) a biocompatible film comprising a polymer film, and the graphene-catalysts conjugate embedded in the polymer film; (2) a biomedical device comprising a main body portion, and a surface coating on the main body portion, where the surface coating includes the graphene-catalysts conjugate embedded in the surface coating; (3) making the graphene-catalysts conjugate comprising covalently linking the second catalyst to a conjugate of the graphene support and the first catalyst; (4) making the biocompatible film comprising coating a surface with a composition comprising the polymer mixed with the graphene-catalysts conjugate; (5) making the biomedical device comprising coating the main body portion with a composition comprising the graphene-catalysts conjugate; and (6) improving the antithrombotic property of an implant, comprising coating the implant with a composition comprising the graphene-catalysts conjugate.