• 专利标题:   Flexible sensor electrode useful in preparing flexible sensor, comprises flexible base layer, conductive layer disposed on flexible base layer, graphene layer disposed on conductive layer, and modified layer disposed on graphene layer.
  • 专利号:   CN112957039-A
  • 发明人:   ZHANG X, JIN X, XU T, SU L
  • 专利权人:   UNIV SHENZHEN
  • 国际专利分类:   A61B005/1486, A61K050/00
  • 专利详细信息:   CN112957039-A 15 Jun 2021 A61B-005/1486 202164 Pages: 18 Chinese
  • 申请详细信息:   CN112957039-A CN10163217 05 Feb 2021
  • 优先权号:   CN10163217

▎ 摘  要

NOVELTY - Flexible sensor electrode comprises a flexible base layer, a conductive layer disposed on the flexible base layer, a graphene layer disposed on the conductive layer, and a modified layer disposed on the graphene layer. The modified layer includes a conductive polymer and a biological enzyme. The conductive polymer and the biological enzyme are connected by an amide bond. The conductive polymer includes poly(N-phenylglycine) and/or poly(N-phenylglycine) derivatives. USE - The flexible sensor electrode is useful in preparing flexible sensor (claimed). ADVANTAGE - The flexible sensor electrode has excellent flexibility and biocompatibility; reduces the damage caused when the electrode is implanted in the human body; alleviates the suffering of the patient; has high detection sensitivity, low working potential and excellent structural stability; and can improve the sensitivity of the flexible sensor, enhance the anti-interference, reduce the detection limit, and expand the concentration detection range. DETAILED DESCRIPTION - Flexible sensor electrode comprises a flexible base layer, a conductive layer disposed on the flexible base layer, a graphene layer disposed on the conductive layer, and a modified layer disposed on the graphene layer. The modified layer includes a conductive polymer and a biological enzyme. The conductive polymer and the biological enzyme are connected by an amide bond. The conductive polymer includes poly(N-phenylglycine) and/or poly(N-phenylglycine) derivatives. An INDEPENDENT CLAIM is also included for preparing flexible sensor, comprising providing a flexible base layer, forming a conductive layer on the surface of the flexible base layer, and etching the conductive layer to form a working electrode, a counter electrode and a reference electrode, preparing a graphene layer by plasma enhanced chemical vapor deposition, and transferring the graphene layer to the surface of the working electrode, mixing the conductive polymer, the biological enzyme and the solvent to obtain modified layer solution, coating the modified layer solution on the surface of the graphene layer, and drying to obtain final product.