• 专利标题:   Inducing growth of nerve cells e.g. spindle cells, by providing graphene oxide layer, selectively irradiating laser in desired pattern of graphene oxide layer and attaching and growing nerve cells to pattern region of reduced graphene oxide.
  • 专利号:   KR2019124395-A, KR2062563-B1
  • 发明人:   KANG K T, LEE M H, LEE H B, LEE S H, KIMYOONYOUNG
  • 专利权人:   UNIV KYUNGHEE IND COOP
  • 国际专利分类:   C04B035/52, C04B035/622, C04B041/00, C12N005/00, C12N005/0793
  • 专利详细信息:   KR2019124395-A 05 Nov 2019 C12N-005/0793 201998 Pages: 17
  • 申请详细信息:   KR2019124395-A KR048305 26 Apr 2018
  • 优先权号:   KR048305

▎ 摘  要

NOVELTY - Method for inducing growth of nerve cells involves (a) providing a graphene oxide layer, (b) selectively irradiating a laser in a desired pattern with respect to the graphene oxide layer, where the laser provides energy to reduce at least a portion of the graphene oxide in the irradiated pattern region and surface roughness is formed in the pattern region of the reduced graphene oxide, and (c) attaching and growing nerve cells to the pattern region of the reduced graphene oxide. USE - The method is useful for inducing growth of nerve cells chosen from hippocampal neurons, spinal motor neurons, dorsal root ganglion, retinal ganglion neurons, Golgi I neurons, Golgi II neurons, basket cells, betz cells, lugaro cells, medium spiny neurons, Purkinje cells, Renshaw cells, unipolar brush cells, granule cells, anterior horn cells, motoneurons, spindle cells, pseudounipolar neurons, multipolar neurons, interneurons, motor neurons, sensory neurons, stellate cells and their combinations (claimed). The method is useful in bioelectronic devices such as carbon-based nerve chips and neural prostheses. ADVANTAGE - The method induces growth of nerve cells in a simple and cost-effective manner with reduced manufacturing processes.