• 专利标题:   Preparing whole-target antigen presenting cell tumor vaccine comprises e.g. co-incubating quantum dot modified tumor cell and immature antigen presenting cell, where quantum dot modified tumor cell obtained by connecting quantum dot with protein molecular chain of tumor cell by using hydrogen bond.
  • 专利号:   CN113440607-A, WO2023274299-A1
  • 发明人:   ZHOU Y, TANG Z, QU S
  • 专利权人:   UNIV MACAU
  • 国际专利分类:   A61K039/00, A61K047/46, A61P035/00, C12N005/09
  • 专利详细信息:   CN113440607-A 28 Sep 2021 A61K-039/00 202104 Chinese
  • 申请详细信息:   CN113440607-A CN10731947 30 Jun 2021
  • 优先权号:   CN10731947

▎ 摘  要

NOVELTY - Preparing an whole-target antigen presenting cell tumor vaccine comprises co-incubating a quantum dot modified tumor cell and an immature antigen presenting cell, where the quantum dot modified tumor cell is obtained by connecting a quantum dot with a protein molecular chain of a tumor cell by using a hydrogen bond in a ligand manner. USE - The whole-target antigen presenting cell tumor vaccine is useful in preparing medicine for treating or preventing tumor, preferably lung cancer cells, breast cancer cells, ovarian cancer cells, renal cancer cells, nasopharyngeal carcinoma cells, esophageal cancer cells, colorectal cancer cells, malignant glioma cells, and epithelial cell-derived malignant cells of brain myeloma cells (all claimed). ADVANTAGE - The vaccine enhances the uptake of the tumor antigen and increases the major histocompatibility complex (MHC) molecule expression on a large scale and improves the antigen presenting efficiency, and is prepared by simple process and economical. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for whole-target antigen presenting cell tumor vaccine prepared by above method.