▎ 摘　　要

NOVELTY - Making many conjugates, where each conjugate comprises graphene quantum dot (GQD), targeting moiety conjugated to the GQD, and active agent associated with the GQD, the targeting moiety is folic acid or derivative, and the active agent is doxorubicin non-covalently associated with the GQD via pi - pi stacking, comprises: conjugating the targeting moiety to each GQD in the conjugates to form many first intermediates, where the targeting moiety is folic acid or a derivative thereof, the conjugating the targeting moiety to each GQD comprises reacting each GQD with ammonium hydroxide and hydrogen peroxide to introduce amine reactive coupling groups onto each of the GQDs and reacting the targeting moiety with crosslinking agents to form a covalent bond with the amine reactive coupling group to form the first intermediates; and associating the active agent to each first intermediate in the first intermediates to form the conjugates. USE - The method is useful for making many conjugates (claimed) for therapeutic, prophylactic, or diagnostic effects to a subject, where the subject is cancer patient and the active agent an anti-cancer agent. No biological data given. DETAILED DESCRIPTION - Making many conjugates, where each conjugate comprises a graphene quantum dot (GQD), a targeting moiety conjugated to the GQD, and an active agent associated with the GQD, the GQDs in the conjugates have an average diameter of 3 nm and a span of less than or equal to 1.5, the targeting moiety is folic acid or a derivative, and the active agent is a doxorubicin non-covalently associated with the GQD via pi - pi stacking, comprises: conjugating the targeting moiety to each GQD in the conjugates to form many first intermediates, where the targeting moiety is folic acid or a derivative thereof, the conjugating the targeting moiety to each GQD comprises reacting each GQD with ammonium hydroxide and hydrogen peroxide to introduce amine reactive coupling groups onto each of the GQDs and reacting the targeting moiety with crosslinking agents to form a covalent bond with the amine reactive coupling group to form the first intermediates; and associating the active agent to each first intermediate in the first intermediates to form the conjugates.