▎ 摘　　要

NOVELTY - Manufacture of polymer nanoparticle-doped polymer antibacterial fiber membrane involves adding 100-200 mg yttrium(III) chloride and 1-50 mg thulium(III) chloride to deionized water to obtain mixed solution (A), adding 0.5-2 g sodium hydroxide, 1-5 mL water, 5-15 mL ethanol, and 10-50 mL oleic acid, stirring to get mixed solution(B), adding mixed solution(B) to solution (A), stirring at room temperature, transferring to polytetrafluoroethylene reactor, reacting in oven at 180-200 degrees C for 6-24 hours, cooling to room temperature, stirring, mixing 0.05-0.2 g upconversion nanoparticles-doped titanium dioxide with 1-5 mg graphene oxide in 20-30 mL water, stirring, adding 5-30% upconversion nanoparticles-doped titanium dioxide-doped graphene oxide composite nanoparticles relative to mass of polyvinylidene fluoride, and supporting polyvinylidene fluoride composite fiber membrane by nanoparticles. USE - Manufacture of polymer nanoparticle-doped polymer antibacterial fiber membrane. ADVANTAGE - The method enables simple and efficient manufacture of polymer nanoparticle-doped polymer antibacterial fiber membrane having high sterilization effect of photodynamics and photothermodynamics. The composite membrane has excellent cell compatibility and can be repeatedly sterilized without harming organism. It will not cause organisms to develop drug resistance, and it will show obvious antibacterial activity against gram-negative bacteria and gram-positive bacteria. DETAILED DESCRIPTION - Manufacture of polymer nanoparticle-doped polymer antibacterial fiber membrane involves adding 100-200 mg yttrium(III) chloride and 1-50 mg thulium(III) chloride to deionized water to obtain mixed solution (A), adding 0.5-2 g sodium hydroxide, 1-5 mL water, 5-15 mL ethanol, and 10-50 mL oleic acid, stirring to obtain mixed solution (B), adding mixed solution(B) to solution (A), stirring at room temperature, transferring to polytetrafluoroethylene reactor, reacting in oven at 180-200 degrees C for 6-24 hours, cooling to room temperature, adding 10-20 mg upconversion nanoparticles to 200 mL n-butyl titanate/water/ethanol (volume/volume = 1/2/100/-1 /2/200), stirring, centrifuging to obtain product, mixing 0.05-0.2 g upconversion nanoparticles doped titanium dioxide with 1-5 mg graphene oxide in 20-30 mL water, stirring, reacting at 120 degrees C for 1-2 hours, centrifuging to obtain product, dissolving 1-3 g polyvinylidene fluoride in mixed solvent of 10 mL N, N-dimethylformamide/acetone (volume/volume = 1/1-3/1), adding 5-30% upconversion nanoparticles doped titanium dioxide doped graphene oxide composite nanoparticles relative to mass of polyvinylidene fluoride, stirring to obtain uniformly mixed electrospinning solution, injecting mixed electrospinning solution in syringe, and supporting polyvinylidene fluoride composite fiber membrane by nano particles is obtained by electrostatic spinning method.