▎ 摘 要
NOVELTY - Synthesizing isocoumarines involes subjecting to Sonogashira cross-coupling reaction followed by intramolecular cyclization, and catalyzing by palladium nanoparticles which is supported on reduced graphene oxide. USE - Method for synthesizing isocoumarines. ADVANTAGE - The method enables to synthesize isocoumarines that has biological properties such as antifungal, cytotoxic, immunomodulatory, antiallergic and anti-tumor.