• 专利标题:   Benefit agent delivery system used to deliver e.g. agent, vaccine, antibody, hormone, protein, and other benefit agents, comprises a first electrode layer, a microcell layer comprising microcells, and porous second electrode layer.
  • 专利号:   WO2023278527-A1, US2023001188-A1
  • 发明人:   KANDADAI M A, ZANG H
  • 专利权人:   E INK CALIFORNIA LLC, E INK CALIFORNIA LLC
  • 国际专利分类:   A61K009/00, A61K009/70, A61M035/00, A61M037/00, A61L009/04, A61L009/12, A61N001/32, C11B009/00
  • 专利详细信息:   WO2023278527-A1 05 Jan 2023 A61K-009/00 202306 Pages: 54 English
  • 申请详细信息:   WO2023278527-A1 WOUS035453 29 Jun 2022
  • 优先权号:   US216818P, US852603

▎ 摘  要

NOVELTY - Benefit agent delivery system comprises: a first electrode layer; a microcell layer comprising microcells, where each microcell including a first opening, and each microcell containing a liquid mixture; a porous second electrode layer spanning the first opening of each microcell, and the first electrode layer, the microcell layer, and the porous second electrode layer being vertically stacked upon each other; the liquid mixture comprising reverse micelles in a hydrophobic liquid that are formed from a polar liquid, a surfactant, and a benefit agent, the surfactant being an anionic surfactant or a cationic surfactant, and where application of a first voltage across a microcell via the first electrode layer and the porous second electrode layer having polarity that causes the migration of the reverse micelles in the microcell towards the porous second electrode increases the rate of release of benefit agent. USE - The system is useful for delivering agent, vaccine, antibody, hormone, protein, nucleic acid, nutrient, nutraceutical agent, cosmetic agent, fragrance, malodor removing agent, air care agent, agricultural agent, air care agent, antimicrobial agent, preservative, and other benefit agents. No biological data given. ADVANTAGE - The system delivers varying amounts of benefit agents from the same delivery system at different times, and multiple benefit agents at the same or different times from the same benefit agent delivery system. DETAILED DESCRIPTION - Benefit agent delivery system comprises: a first electrode layer; a microcell layer comprising microcells, where each microcell including a first opening, and each microcell containing a liquid mixture; a porous second electrode layer spanning the first opening of each microcell, and the first electrode layer, the microcell layer, and the porous second electrode layer being vertically stacked upon each other; the liquid mixture comprising reverse micelles in a hydrophobic liquid that are formed from a polar liquid, a surfactant, and a benefit agent, the surfactant being an anionic surfactant or a cationic surfactant, and where application of a first voltage across a microcell via the first electrode layer and the porous second electrode layer having polarity that causes the migration of the reverse micelles in the microcell towards the porous second electrode increases the rate of release of the benefit agent through the porous second electrode layer compared to the rate of release of the benefit agent through the porous second electrode layer when no voltage is applied, and the application of a second voltage across a microcell via the first and second electrode layers, the second voltage having polarity opposite to first voltage, causes the migration of the reverse micelles in the microcell away from the porous second electrode layer and reduces the rate of release of the benefit agent through the porous second electrode layer compared to the rate of release of the benefit agent through the porous second electrode layer when no voltage is applied An INDEPENDENT CLAIM is also included for operating a benefit agent delivery system, comprising providing a benefit agent delivery system comprising (a) a first electrode layer, (b) a microcell layer comprising microcells, where each microcell including an opening, and microcell containing a liquid mixture, the liquid mixture comprising reverse micelles in a hydrophobic liquid that are formed from a polar liquid, an anionic or cationic surfactant, and a benefit agent, (d) a porous second electrode layer spanning the opening of each microcell, and (e) a voltage source that is coupled to the first electrode layer and the porous second electrode layer, where the first electrode layer, the microcell layer, and the porous second electrode layer are vertically stacked upon each other, applying a first voltage on a microcell via the voltage source that causes the migration of the reverse micelles of the microcell towards the porous second electrode, increasing the rate of release of the benefit agent through the porous second electrode layer compared to the rate of release of the benefit agent through the porous second electrode layer when no voltage is applied, and applying a second voltage on a microcell via the voltage source, the second voltage having polarity opposite to the polarity of the first voltage, that causes the migration of the reverse micelles of the microcell away from the porous second electrode, and reducing the rate of release of the benefit agent through the porous second electrode layer compared to the rate of release of the benefit agent through the porous second electrode layer when no voltage is applied.