• 专利标题:   Multifunctional hollow mesoporous composite drug-loaded material used in drug delivery system, is formed by preparing iron oxide by solvothermal method, adding cetyltrimethylammonium bromide and graphene oxide, and uniformly stirring.
  • 专利号:   CN108671234-A
  • 发明人:   CUI B, BU Y, YANG Z, CHEN P
  • 专利权人:   UNIV NORTHWEST
  • 国际专利分类:   A61K047/04, A61K047/02, A61K045/00, A61P035/00
  • 专利详细信息:   CN108671234-A 19 Oct 2018 A61K-047/04 201902 Pages: 11 Chinese
  • 申请详细信息:   CN108671234-A CN10555276 01 Jun 2018
  • 优先权号:   CN10555276

▎ 摘  要

NOVELTY - A multifunctional hollow mesoporous composite drug-loaded material comprises nano-graphene oxide and iron oxide, and is formed by preparing iron oxide by solvothermal method, adding cetyltrimethylammonium bromide and nano-graphene oxide to the prepared solution, stirring uniformly, and preparing nano-graphene oxide inlaid iron oxide nanocomposite drug-loading material by solvothermal method. USE - Multifunctional hollow mesoporous composite drug-loaded material used in drug delivery system. ADVANTAGE - The composite drug-loaded material has excellent microwave thermal conversion performance and magnetic responsiveness, and high saturation magnetization value and large surface area. The drug loading amount of the carrier can be increased. DETAILED DESCRIPTION - A multifunctional hollow mesoporous composite drug-loaded material comprises nano-graphene oxide and iron oxide, and is formed by preparing iron oxide by solvothermal method, adding cetyltrimethylammonium bromide and nano-graphene oxide to the prepared solution, stirring uniformly, and preparing nano-graphene oxide inlaid iron oxide nanocomposite drug-loading material by solvothermal method. The composite material has compositional formula: Fe3O4/xnGO. x = 1-3. An INDEPENDENT CLAIM is included for preparation of multifunctional hollow mesoporous composite drug-loaded material, which involves dispersing iron chloride hexahydrate and 0.1 g nano graphene oxide in ethylene glycol, uniformly stirring at room temperature to form a dark green solution, adding polyethylene glycol 6000 and cetyltrimethylammonium bromide to the solution, stirring for 30 minutes, mixing, adding sodium acetate, stirring for 2 hours, transferring the solution to polytetrafluoroethylene reactor, heating to 200 degrees C, naturally cooling to room temperature, magnetically separating, and washing with ethanol and water several times.