• 专利标题:   Preparing film used as antibacterial packing material or slow-release drug-carrying material by adding carboxymethyl chitosan and graphene oxide solution to triphosphoric acid, adding gelatin solution, adding into plate and drying film.
  • 专利号:   CN115216039-A
  • 发明人:   ZHAO Y, LI Y, LI F, XIE D, LI C
  • 专利权人:   GUANGDONG ACAD SCI INST BIOLOGICAL MED
  • 国际专利分类:   A61K047/02, A61K047/04, A61K047/36, A61K047/42, B65D065/46, C08J005/18, C08K003/04, C08K003/08, C08L005/08, C08L089/00
  • 专利详细信息:   CN115216039-A 21 Oct 2022 C08J-005/18 202204 Chinese
  • 申请详细信息:   CN115216039-A CN10994106 18 Aug 2022
  • 优先权号:   CN10994106

▎ 摘  要

NOVELTY - Method for preparing film involves (a) dissolving gelatin in deionized water and stirring to obtain a gelatin solution, (b) dripping the silver nitrate solution into the gelatin solution and adding into a UV irradiation instrument for UV reduction to obtain a gelatin solution comprising nano-silver particles, (c) dissolving carboxymethyl chitosan in deionized water and stirring to obtain carboxymethyl chitosan solution, (d) adding graphene oxide to deionized water and ultrasonically dispersing to obtain graphene oxide solution, (e) adding carboxymethyl chitosan solution and graphene oxide solution to triphosphoric acid solution and stirring to obtain carboxymethyl chitosan graphene oxide complex solution, (f) gradually adding the gelatin solution to the carboxymethyl chitosan graphene oxide complex solution and stirring and (g) adding the mixed solution obtained in step (f) into a tetrafluoroethylene plate and drying to obtain a antibacterial film. USE - The method is useful for preparing antibacterial film, which is useful as antibacterial packing material or slow-release drug-carrying material in field of food or medicine (claimed). ADVANTAGE - The method prepares film, which is degradable and has good swelling property, thermal stability, biocompatibility and antibacterial property. DETAILED DESCRIPTION - Method for preparing film involves (a) dissolving gelatin in deionized water and stirring until complete dissolution to obtain a gelatin solution, (b) dripping the silver nitrate solution into the gelatin solution, stirring until the mixture is uniform and adding into a UV irradiation instrument for UV reduction to obtain a gelatin solution comprising nano-silver particles, (c) dissolving carboxymethyl chitosan in deionized water and stirring until complete dissolution to obtain carboxymethyl chitosan solution, (d) adding graphene oxide to deionized water and ultrasonically dispersing to obtain graphene oxide solution, (e) adding carboxymethyl chitosan solution and graphene oxide solution to triphosphoric acid solution in a volume ratio of 10-50:50-90:1 and stirring to obtain carboxymethyl chitosan graphene oxide complex solution, (f) gradually adding the gelatin solution comprising nano-silver particles to the carboxymethyl chitosan graphene oxide complex solution in a volume ratio of 1:5-1:1 and stirring at 30-60°C until uniformly mixed to obtain a mixed solution and (g) adding the mixed solution obtained in step (f) into a tetrafluoroethylene plate and drying at 30-50°C for 24 hours to obtain a antibacterial film.