▎ 摘　　要

NOVELTY - Composition comprises one or more biodegradable agents (e.g., microparticles or a nanoparticles) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) one or more therapeutic agents (e.g., agents capable of treating and/or ameliorating the symptoms of conditions associated with the pancreas (e.g., pancreatic cancer, pancreatitis, diabetes), conditions associated with the bile duct (e.g., cancer associated with the bile duct), conditions associated with the liver (e.g., liver cancer), and/or conditions associated with the gall bladder (e.g., gall bladder cancer)). USE - The composition is useful in kit for treating, preventing, and/or ameliorating symptoms of a condition in a subject. The condition is any disease related to the pancreas (e.g., any type of pancreatic cancer, pancreatitis, diabetes), any disease related to the bile duct (e.g., cholangitis, bile duct leaks, biliary stricture, biliary stones, bile duct cancer (e.g., cholangiocarcinoma)), any disease related to the gall bladder (e.g., gall stones, gall bladder carcinoma), and any disease related to the liver (e.g., hepatitis, cholangitis, biliary atresia, α 1 antitrypsin deficiency, alagille syndrome, progressive familial intrahepatic cholestasis, Langerhans cell histiocytosis, hepatic hemangioma, polycystic liver disease, liver cancer) (all claimed). ADVANTAGE - The composition has improved bioavailability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: a method for treating, preventing, and/or ameliorating symptoms of a condition in a subject, involves administering the composition; and a kit comprising (a) the composition and (b) one or more of therapeutic agents, and an agent capable of relaxing (e.g., opening, dilating) the hepatopancreatic anatomical region in the subject (e.g., nitroglycerin, scopolamine butylbromide, hymecromone (7-hydroxy-4-methylumbelliferone), botulinum toxin, vasoactive intestinal polypeptide, cholecystokinin-8, and secretin).