▎ 摘　　要

NOVELTY - A gold-coated poly-(lactic co-glycolic acid) nanostructures comprise a d-α Tocopheryl polyethylene glycol succinate, and a cationic polymer responsive to near-infra red absorption for multimodal imaging and targeted photothermal therapy of cancer. The gold-coated poly-(lactic co-glycolic acid) nanostructures is coated with ligand (L) for cell surface receptor (C') and with bioimaging agent. USE - Gold-coated poly-(lactic co-glycolic acid) nanostructures e.g. nanoshells, branched spheres, and multipods (all claimed) used for biological applications e.g. multimodal imaging and actively targeted photothermal therapy of cancer. ADVANTAGE - The gold-coated poly-(lactic co-glycolic acid) nanostructures bind to malignant tumor cells and cause their ablation in a highly controlled manner. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for manufacture of the gold coated poly-(lactic-co-glycolic acid) nanostructures, which involves functionalizing poly-(lactic-co-glycolic acid) with a cationic polymer and emulsifier, coating the functionalized poly-(lactic-co-glycolic acid) with gold, coating the gold coated functionalized poly-(lactic-co-glycolic acid) with the ligand (L), and bioimaging agent.