• 专利标题:   Use of metal-polyphenol network for preparation of material for promoting bone tissue repair for treating, or repairing bone defect.
  • 专利号:   CN113769166-A, CN113769166-B
  • 发明人:   HUANG L, LI Q, HUANG K, YUAN Q, TAN J, ZHANG Q, XIE H
  • 专利权人:   UNIV SICHUAN WEST CHINA HOSPITAL
  • 国际专利分类:   A61L027/28, A61L027/50, A61L027/54
  • 专利详细信息:   CN113769166-A 10 Dec 2021 A61L-027/28 202219 Chinese
  • 申请详细信息:   CN113769166-A CN11131745 26 Sep 2021
  • 优先权号:   CN11131745

▎ 摘  要

NOVELTY - Use of metal-polyphenol network is claimed for preparing material for promoting bone tissue repair, where polyphenol in metal and polyphenolic network is selected from protocatechuic aldehyde, proanthocyanidins, tannic acid or epigallocatechin gallate; and metal ion in metal polyphenols network is zinc (Zn (II)) ion, magnesium ion or copper ion. USE - Metal-polyphenol network used for preparing material for promoting bone tissue repair, where material is used for treating or repairing bone defect, preferably eliminating oxidative stress, inhibiting inflammation, modulating immune microenvironment, promoting osteoblast regeneration and promoting mineralization; and bone repair material used for preparation of bone film (all claimed). ADVANTAGE - The metal-polyphenol network enables to prepare bone repairing material, which has good hydrophilicity, mechanical property and biological compatibility, and effectively reduces oxidative stress, has bone inductivity and immune regulation function, and effectively promote regeneration of bone defect, promotes bone defect regeneration repair. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a bone repairing material, which comprises substrate, where surface of substrate covered with metal-polyphenol network; (2) a method for preparing bone repairing material, which involves: (a) preparing mixed solution of polyphenol, and metal ion; (b) immersing base material in mixed solution to react; (c) obtaining product; (3) a bone film, which is prepared by repairing material, where shape of base material, which is film-shaped block-shaped, or granular film. DESCRIPTION OF DRAWING(S) - Adding sodium hypochlorite (10) Cellulose molecular weight (60)