• 专利标题:   Cotton gauze reinforced hydrogel conductive dressing with photothermal antibacterial and healing promoting effect used for treatment and management of wounds prone to infection comprises a cotton gauze substrate on which photothermal components, calcium ions and conductive components.
  • 专利号:   CN113694244-A, CN113694244-B
  • 发明人:   WANG L, ZHANG J, YUAN X, GAO J
  • 专利权人:   UNIV DONGHUA
  • 国际专利分类:   A61L015/18, A61L015/24, A61L015/40, A61L015/42, A61L015/44, D06M101/06, D06M011/74, D06M015/13, D06M015/37
  • 专利详细信息:   CN113694244-A 26 Nov 2021 A61L-015/18 202226 Chinese
  • 申请详细信息:   CN113694244-A CN11019756 01 Sep 2021
  • 优先权号:   CN11019756

▎ 摘  要

NOVELTY - Cotton gauze reinforced hydrogel conductive dressing with photothermal antibacterial and healing promoting effect comprises a cotton gauze substrate on which photothermal components, calcium ions and conductive components, where the photothermal component is polydopamine-modified graphene oxide (rGO-PDA). The conductive component is polypyrrole. The photothermal component, calcium ion and conductive component has a cross-linked network structure. USE - The dressing is useful for the treatment and management of wounds prone to infection. ADVANTAGE - The dressing has good mechanical, photothermal antibacterial, electrical conductivity, water absorption and moisturizing, antioxidant activity and biocompatibility properties; provides necessary mechanical support for wounds; and meets the requirements of non-antibiotic, photothermal, antibacterial, conductive and healing effects of medical dressings in the process of wound healing. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method for preparing cotton gauze reinforced hydrogel conductive dressing with photothermal antibacterial and healing promoting effect comprising (1) adding graphene oxide and dopamine hydrochloride to a tris-hydrochloric acid solution with a pH of 8.5, ultrasonically dispersing in an ice bath, reacting the mixture under magnetic stirring, filtering and drying to obtain a polydopamine-modified graphene oxide (rGO-PDA), (2) adding the cross-linking agent and polydopamine-modified graphene oxide to the sodium alginate aqueous solution, mixing evenly, placing the cotton gauze in the solution, sealing, and allowing to stand to obtain the cotton gauze reinforced hydrogel, and (3) immersing the cotton gauze-reinforced hydrogel in a ferric chloride solution, and then immersing in a pyrrole monomer solution under ice bath conditions, and polymerizing the pyrrole monomer into the hydrogel in situ.