▎ 摘　　要

NOVELTY - Enzyme-TiO2 nanotube-quantum dot co-assembly catalyzed synthesis comprises (a) using aldo-ketone reductase as a model, using the cell disrupted supernatant by microwave, covalently cross-linking the aldehyde-ketone reductase with a diacetylenic cross-linking agent to form an enzyme-protein assembly, (b) using the reduced graphene quantum dots to combine with TiO2 nanotubes to form TiO2/r-GQDs composites, (c) using TiO2/r-GQDs as photocatalyst, rhodium ligand as electron transfer agent, and water as hydrogen donor, carrying out the regeneration of cofactor NADPH under infrared light, establishing photo-enzyme catalytic system to obtain enzyme-TiO2 nanotube-quantum dot co-assembled composite catalytic material, and (d) catalytically synthesizing key medicinal intermediates through enzyme-TiO2 nanotube-quantum dot co-assembly under infrared light. USE - Enzyme-TiO2 nanotube-quantum dot co-assembly catalyzed synthesis. ADVANTAGE - The method realizes chemical reaction driven by infrared light through the co-assembly of the enzymatic TiO2 nanotube quantum dots, improved light utilization rate is expected to contribute to the development of green and sustainable catalytic synthesis of fine chemicals and medicinal intermediates.