• 专利标题:   Chemotactic antibacterial nanomaterial used in an antibacterial biological agent, comprises graphene oxide and polydopamine coated on surface of graphene oxide, and its surface is adsorbed with peptide loaded with chemotactic agent.
  • 专利号:   CN111529682-A
  • 发明人:   ZHAN R, LUO G, XIAO L, GUO Y, NI W
  • 专利权人:   UNIV ARMY MEDICAL FIRST AFFILIATED HOSPI
  • 国际专利分类:   A61K038/08, A61K041/00, A61K047/04, A61K047/34, A61P031/04
  • 专利详细信息:   CN111529682-A 14 Aug 2020 A61K-038/08 202076 Pages: 19 Chinese
  • 申请详细信息:   CN111529682-A CN10392016 11 May 2020
  • 优先权号:   CN10392016

▎ 摘  要

NOVELTY - Chemotactic antibacterial nanomaterial comprises graphene oxide and polydopamine coated on surface of graphene oxide, and its surface is adsorbed with antibacterial peptide. The antibacterial peptide is loaded with a chemotactic agent through a chemical reaction. USE - Chemotactic antibacterial nanomaterial used in an antibacterial biological agent (claimed). ADVANTAGE - The chemotactic antibacterial nanomaterial solves problem of bacteria invading organism, bacteria and medicine remaining in tissue. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing a chemotactic antibacterial nanomaterial, which involves: (A) adding dopamine hydrochloride to Tris-HCl buffer, adding graphene oxide for performing ultrasonic treatment, stirring it to coat surface of graphene oxide with polydopamine, and centrifuging it to obtain PDA@GO; (B) adding antimicrobial peptide and PDA@GO to Tris-HCl buffer, stirring it to adsorb antimicrobial peptide on the polydopamine surface, and centrifuging it to obtain the antimicrobial peptide-PDA@GO; and (C) dissolving chemotactic agent in Tris-HCl buffer to obtain chemotactic agent solution, adding NHS, stirring it for 2-3 hours at 25-30 degrees C, adding EDC and antimicrobial peptide-PDA@GO, stirring it to load chemotactic agent on antimicrobial peptide through dehydration condensation reaction, and centrifuging it to obtain the chemotactic antimicrobial nanomaterial which is named as chemotactic agent/antimicrobial peptide-PDA@GO.