• 专利标题:   Preparation of collagen/graphene oxide nanofiber composite film involves mixing graphene oxide solution, and solution obtained by dissolving collagen in hexafluoroisopropanol, electrospinning, and crosslinking using crosslinking agent.
  • 专利号:   CN104761737-A, CN104761737-B
  • 发明人:   WANG M, WU Q
  • 专利权人:   UNIV WUHAN TECHNOLOGY
  • 国际专利分类:   C08J003/24, C08K003/04, C08K009/00, C08L089/00, D04H001/728
  • 专利详细信息:   CN104761737-A 08 Jul 2015 C08J-003/24 201572 Pages: 8 Chinese
  • 申请详细信息:   CN104761737-A CN10179337 15 Apr 2015
  • 优先权号:   CN10179337

▎ 摘  要

NOVELTY - Graphene oxide or its derivative is placed in deionized water, and dispersed to obtain graphene oxide or its derivative solution (A). Collagen is added to hexafluoroisopropanol, and dissolved to obtain solution (B). The solution (A) is added to solution (B) to obtain solution (C). The solution (C) is subjected to electrospinning process, obtained film is placed in mixed solution (E) of crosslinking agent and acetone, crosslinked collagen/oxidized graphene nanofiber composite film is washed with deionized water and dried to obtain collagen/graphene oxide nanofiber composite film. USE - Preparation of collagen/graphene oxide nanofiber composite film (claimed). ADVANTAGE - The method provides collagen/graphene oxide nanofiber composite film having excellent mechanical property, and large surface area. DETAILED DESCRIPTION - Graphene oxide or its derivative is placed in deionized water, ultrasonic processing is carried out and dispersed uniformly to obtain graphene oxide or its derivative solution (A). Collagen is added to hexafluoroisopropanol, stirred and dissolved to obtain solution (B). The solution (A) is added to solution (B) and stirred to obtain solution (C). The obtained solution (C) is transferred to electrospinning apparatus, and electrospinning is carried out at 20-25 degrees C and voltage of 10-20 KV, at a speed of 0.02-2 mm/minute and relative humidity of 50-60%. The obtained film is placed in a mixed solution (E) of crosslinking agent and acetone, crosslinked for 24 hours, the crosslinked collagen/oxidized graphene nanofiber composite film is washed with deionized water and dried to obtain collagen/graphene oxide nanofiber composite film. The volume ratio of solution (C) and solution (B) is 1:1. The concentration of collagen is 8-16 wt.%/vol.%.