• 专利标题:   Biosensing chip for distinguishing lesion site of cancer cells, comprises substrate comprising photoelectric conversion material, e.g. monocrystalline silicon material, and electrode comprising two contact portions and electrode pattern.
  • 专利号:   US2021318313-A1, JP2021168642-A, TW202137942-A, JP7010516-B2
  • 发明人:   WANG S, FAN H, JEN C, WANG H
  • 专利权人:   UNIV NAT CHUNG CHENG, UNIV NAT CHUNG CHENG, UNIV NAT CHUNG CHENG
  • 国际专利分类:   G01N033/543, G01N033/574, C12M001/34, C12Q001/06, A61B018/14, A61B008/08, G01N033/50, B26D003/28
  • 专利详细信息:   US2021318313-A1 14 Oct 2021 G01N-033/574 202101 English
  • 申请详细信息:   US2021318313-A1 US933125 20 Jul 2020
  • 优先权号:   TW112515

▎ 摘  要

NOVELTY - Biosensing chip (1) comprises a substrate comprising a photoelectric conversion material; and an electrode (2) disposed on the substrate and comprising two contact portions and an electrode pattern (3). The photoelectric conversion material is a monocrystalline silicon material, a metal oxide, an III-V compound semiconductor, or an II-VI compound semiconductor material. USE - The biosensing chip is useful for distinguishing lesion site of cancer cells; and for distinguishing degree of cancer lesions (all claimed). ADVANTAGE - The biosensing chip only requires a small amount of time to detect and analyze cancer cells without complicated and expensive equipment. Compared to the thermal resistance vapor deposition method in the past, the method may not only overcome the limitation on the target material, but also effectively reduce the pollution that may be caused during vapor deposition. The resolution and precision provided by the micro-current meter are superior to those provided by a more expensive conventional instrument, and the micro-current meter also provides more silent and stable measurement and greatly shortens the time for measurement. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) distinguishing a lesion site of cancer cells, which involves applying a cell suspension liquid comprising a test cell after being quantified to an electrode pattern of the biosensing chip; applying an electric signal to two contact portions of the biosensing chip by a signal generator; and connecting a sensor to the two contact portions of the biosensing chip to measure an admittance value of the test cell; and (2) distinguishing a degree of cancer lesions, which involves applying a cell suspension liquid after being quantified to an electrode pattern of the biosensing chip; connecting a sensor to the two contact portions of the biosensing chip to sense signals; waiting for a first predetermined time to stabilize the biosensing chip in a dark room; turning on a light for a second predetermined time, then turning off the light and lasting for a third predetermined time, and collecting values of a photocurrent response by the sensor.