▎ 摘　　要

NOVELTY - Whole blood perfusion adsorbent comprises a large-size nanofiber porous network microsphere compounded with a natural polymer nanofiber and an inorganic functional filler, an organic functional filler and/or an organic coating material, where the inorganic functional filler and the organic functional filler are wrapped in a natural polymer nanofiber microsphere, and the organic coating material coats the surface of the natural polymer nanofiber microsphere, the diameter of the nanofiber is 5-50 nm, the pore size distribution is 2-40 nm, the maximum pore distribution is 5-15 nm, and the specific surface area is 20-500 m2/g. USE - The whole blood perfusion adsorbent is useful in plasma perfusion, toxin adsorption, water pollution treatment and gas purification field (claimed). ADVANTAGE - The whole blood perfusion adsorbent: has microsphere size suitable for whole blood perfusion, good blood compatibility, nano fiber porous network structure, inorganic and organic functional material with specific adsorption toxin, high adsorption efficiency, strong selectivity; can design corresponding whole blood perfusion adsorbent for specific toxin; and is easy to popularize and apply. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing whole blood perfusion adsorbent comprising (a), when preparing a large-size nanofiber porous network microsphere compounded with a natural polymer nanofiber and an inorganic functional filler or an organic functional filler, comprising the following steps (a1) crushing the inorganic functional filler into particles with a size of 0.01-50 mu m, (a2) dispersing natural polymer powder in a mixed solvent of alkali, urea and deionized water, performing multiple freezing-thaw cycles, defoaming and removing undissolved impurities to obtain a uniform natural polymer solution, and storing the solution for later use at 0-5 degrees C, (a3) adding the inorganic functional filler or the organic functional filler in step (a1) into the solution prepared in the step (a2), stirring under the condition of 0-5 degrees C, centrifuging and defoaming, and preserving the mixture for standby at 0-5 degrees C or adding the inorganic functional filler or the organic functional filler in the step (a1) into a mixed solvent of alkali, urea and deionized water in the step (a2), adding the natural polymer powder, performing multiple freeze-thaw cycles, defoaming and removing undissolved impurities, and storing at 0-5 degrees C, (a4) injecting the solution obtained in the step (a3) into a coagulation bath at a speed of 0.02-2 m/minutes at a speed of less than 5 degrees C, where the injection aperture is 0.06-2 mm, and continuously reacting for 0.5-8 hours at 0-100?Oc, or adding the solution obtained in (a3) into a mixed solution of an organic phase and a dispersing agent, and stirring to form a uniform pellet under the condition of 0-5 degrees C, heating the system to 30-90 degrees C or adding a cross-linking agent for curing reaction, dropwise adding the solidified dispersion liquid into a reaction system for continued reaction, (a5) filtering the sample obtained in the step (a4), pouring into a coagulation bath. allowing to stand, and washing to obtain a large-size nanofiber microsphere compounded with a natural polymer nanofiber and an inorganic functional filler or an organic functional filler, or (b) when preparing a large-size nanofiber porous network microsphere compounded with an inorganic functional filler or an organic functional filler and/or an organic functional filler and/or an organic coating material, the method comprises the following steps: (b1) dispersing natural polymer powder in a mixed solvent of alkali, urea and deionized water, performing multiple freezing-thaw cycles, defoaming and removing undissolved impurities to obtain a uniform natural polymer solution, and storing the solution at 0-5 degrees C, (b2) injecting the solution obtained in the step (b1) into a coagulation bath at a speed of 0.02-2 m/minutes at a speed of less than 5 degrees C, where the injection aperture is 0.06-2 mm, and continuously reacting for 0.5-8 hours under a certain curing condition, and then pouring the obtained product into a coagulation bath, allowing to stand and washing to obtain the large-size natural high-molecular nano-fiber microsphere, adding the solution obtained in the step (b1) into a mixed solution of an organic phase and a dispersing agent, and stirring under the condition of 0-5 degrees C until uniform pellets are formed, heating the system to 30-90 degrees C or adding a cross-linking agent for curing reaction, dropwise adding the solidified dispersion liquid into a reaction system, continuing to react, cooling to room temperature, allowing to stand for layering after the reaction is finished, and taking the lower layer to obtain large-size natural polymer nanofiber microspheres, (b3) adding the large-size nanofiber microspheres obtained in the step a5 or the natural polymer nanofiber microspheres obtained in the step b2 into a cross-linking agent, reacting for 2-10 hours under a certain temperature condition and washing to obtain cross-linked large-size nanofiber microspheres, adding the cross-linked large-size nanofiber microspheres obtained in the step (b3) into an organic coating material reagent, reacting for 2-10 hours under certain conditions, and washing to obtain the large-size nanofiber porous network microsphere with the surface-loaded organic coating material.