▎ 摘　　要

NOVELTY - A graphene oxide derivative is prepared by using covalently linked aromatic azo compound and graphene oxide or covalently linked polysaccharide compound and graphene oxide through glycosidic bonds in which weight ratio of aromatic azo compound or polysaccharide compound and graphene oxide is 5:1-17:4, aromatic azo compound is 4,4'-azodianiline, 4,4'-dimethyl acrylamide azobenzene, 4,4'-bis(N-methacryloyl-6-aminohexanoylamino)azobenzene, 3,3',5,5'-tetrabromo-4,4,4,4 '-tetrakis(methacrylamide)azobenzene, or 4-methacryloyloxy azobenzene, and polysaccharide compound is chitosan, and pectin. USE - A graphene oxide derivative for oral colon-targeted hydrogel framework used for making oral nano-hydrogel colon cancer treating drug (all claimed). ADVANTAGE - Graphene oxide derivative has excellent biological compatibility, water-solubility, and stability, effectively increases drug concentration and curative effect, reduces drug distribution in non-pathological part of human body, and toxic side effects to normal organs and tissues, and realizes tumor-specific targeting. DETAILED DESCRIPTION - A graphene oxide derivative is prepared by using covalently linked aromatic azo compound and graphene oxide or covalently linked polysaccharide compound and graphene oxide through glycosidic bonds in which weight ratio of aromatic azo compound or polysaccharide compound and graphene oxide is 5:1-17:4, aromatic azo compound is 4,4'-azodianiline, 4,4'-dimethyl acrylamide azobenzene, 4,4'-bis(N-methacryloyl-6-aminohexanoylamino)azobenzene, 3,3',5,5'-tetrabromo-4,4,4,4 '-tetrakis(methacrylamide)azobenzene, or 4-methacryloyloxy azobenzene, and polysaccharide compound is chitosan, pectin, guar gum, konjac glucomannan, dextran, amylose, or inulin. An INDEPENDENT CLAIM is included for oral colon-targeted hydrogel framework comprises graphene oxide derivative and pharmaceutically active colon cancer treating drug or pharmacologically active molecule drug-loading nano-layer in which pharmacologically active molecule drug-loading nano-layer and water-soluble polymer which is polyvinyl alcohol with polymerization degree of 1500-3000 and alcoholysis degree of 88-100% is reacted with graphene oxide derivative, pharmaceutically active drug for treatment of colon cancer has aromatic ring and pi electron 5-fluorouracil, capecitabine, curcumin, indomethacin, or hydroxylcamptothecin, and weight ratio of graphene oxide derivative and pharmaceutically active drug for treatment of colon cancer or pharmacologically active molecule drug-loading nano-layer is 1:1-1:5.