• 专利标题:   Composite material used for wound healing, comprises physical antibacterial material comprising graphene oxide or carbon nanotubes coated with protamine comprising pure protamine, protamine sulfate, protamine hydrochloride, and protamine fragments after enzyme digestion.
  • 专利号:   CN113402722-A, CN113402722-B
  • 发明人:   FENG X, WANG J, SHEN J, ZHANG X, ZHANG Y, YANG Z
  • 专利权人:   UNIV YUNNAN
  • 国际专利分类:   C08G083/00, C08J005/18, C08J003/075, A01N047/44, A01N025/34, A01P001/00, C08L087/00
  • 专利详细信息:   CN113402722-A 17 Sep 2021 C08G-083/00 202191 Pages: 10 Chinese
  • 申请详细信息:   CN113402722-A CN10607185 28 May 2021
  • 优先权号:   CN10607185

▎ 摘  要

NOVELTY - A composite material comprises a physical antibacterial material comprising graphene oxide and/or carbon nanotubes coated with protamine comprising one or more of pure protamine, protamine sulfate, protamine hydrochloride, and protamine fragments after enzyme digestion. USE - Composite material used for wound healing. ADVANTAGE - The composite material has a synergistic effect of protamine and antibacterial material that enhances the stability, avoids loss, increases service life and storing time, and improves wound healing. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of the composite material, which involves adding protamine into sterile water, stirring, completely dissolving, obtaining solution comprising 0.5-10 g/L protamine, adding physical antibacterial material into sterile water, ultrasonically dispersing, completely dissolving, obtaining solution comprising 0.5-10 g/L antibacterial material, mixing protamine solution and the antibacterial solution in the volume ratio of 10:1-1:100, heating to 30-100 degrees C for 10-1000 minutes, obtaining a composite suspension, adding 0.1-50 %mass gelling agent, transferring into a mold, vacuum filtering, drying, and separating from the bottom membrane.