▎ 摘　　要

NOVELTY - Solvent-free leakage high impact polyethylene medical packaging material comprises 60-80 pts. wt. modified polyethylene, 1-5 pts. wt. zinc stearate, 2-8 pts. wt. diatomite, 2-8 pts. wt. silicon dioxide, 3-10 pts. wt. dipentyl phthalate and 5-10 pts. wt. graphene. The modified polyethylene is prepared by (A1) mixing and reacting 2,6-dinitrotoluene, acetone and sulfuric acid solution to prepare Intermediate 1, (A2) adding the intermediate 3 to the sodium hypochlorite solution, stirring and reacting, (A3) mixing and reacting intermediate 7, tin powder and concentrated hydrochloric acid, (A4) mixing intermediate 9, palladium hydroxide and tetrahydrofuran homogeneously, and (A5) adding polyethylene into the reaction kettle, extracting the precipitate with methanol and acetone respectively, and drying to obtain modified polyethylene. USE - The solvent-free leakage high impact polyethylene medical packaging material is useful for packaging oral liquid medicine and healthcare product packaging more than 90 % or using glass bottle and PET bottle. ADVANTAGE - The modified polyethylene molecule contains large number of quaternary ammonium salt structures, the quaternary ammonium salt cations adsorb the bacteria together through electrostatic action, the aliphatic hydrocarbon group on the nitrogen atom of the quaternary ammonium salt has lipophilicity and can be inserted into the bacterial cell membrane, which can be closely combined with the hydrophobic group of the phospholipid molecular layer, destroying the skeleton structure of the cell membrane, causes the outflow of cell fluid, the anti-fungal effect will not decrease due to the increase of use time, adding diatomite, silicon dioxide and graphene in the preparation process greatly improves the impact resistance of the medicinal packaging material. DETAILED DESCRIPTION - Solvent-free leakage high impact polyethylene medical packaging material comprises 60-80 pts. wt. modified polyethylene, 1-5 pts. wt. zinc stearate, 2-8 pts. wt. diatomite, 2-8 pts. wt. silicon dioxide, 3-10 pts. wt. dipentyl phthalate and 5-10 pts. wt. graphene. The modified polyethylene is prepared by (A1) mixing and reacting 2,6-dinitrotoluene, acetone and sulfuric acid solution to prepare Intermediate 1, mixing and refluxing Intermediate 1, deionized water and potassium permanganate and reacting, obtaining Intermediate 2, and mixing and refluxing intermediate 2, 2,2,6,6-tetramethylpiperidinol, acetonitrile and copper sulfate and reacting to obtain intermediate 3, (A2) adding the intermediate 3 to the sodium hypochlorite solution, stirring and reacting to obtain the intermediate 4, adding the intermediate 4, N-bromosuccinimide, benzoyl peroxide and carbon tetrachloride to the reaction kettle, reacting to obtain intermediate 5, mixing and refluxing intermediate 5, potassium carbonate, deionized water and tetraethylammonium bromide to prepare intermediate 6, uniformly mixing intermediate 6, silver oxide, benzyl bromide and N,N-dimethylformamide, and stirring and reacting to obtain intermediate 7, (A3) mixing and reacting intermediate 7, tin powder and concentrated hydrochloric acid, adjusting the pH value of the reaction solution to obtain the intermediate 8, mixing N,N-dimethyldodecyl tertiary amine and epichlorohydrin, adding intermediate 8, N,N-dimethylformamide and triphenylphosphine, and continuing reacting to obtain intermediate 9, (A4) mixing intermediate 9, palladium hydroxide and tetrahydrofuran homogeneously, stirring and feeding hydrogen, reacting to obtain intermediate 10, which is dissolved in N,N-dimethylformamide, adding 3-bromopropyltrimethoxysilane, bromopropene and sodium carbonate and reacting to obtain Intermediate 11, and (A5) adding polyethylene into the reaction kettle, passing nitrogen protection, adding deionized water, xylene, dibenzoyl peroxide, intermediate 11, after heat preservation, reacting, washing using chloroform, dissolving in xylene, adding with methanol, precipitating again, extracting the precipitate with methanol and acetone respectively, and drying to obtain modified polyethylene. An INDEPENDENT CLAIM is also included for preparing the medical packaging material, comprising uniformly mixing modified polyethylene, zinc stearate, diatomite, silicon dioxide and dipentyl phthalate and adding into a twin-screw extruder, when the aspect ratio is 25, the screw speed is 180 revolutions/minute, the temperature of each section is 160°C, 220°C, 230°C, 235°C, 240°C, 245°C, 245°C, 250°C, 250°C and 255°C, respectively, under the condition that the vacuum degree of each section is 0.02 MPa, blending, extruding, dicing and cooling to obtain medical packaging materials.