▎ 摘　　要

NOVELTY - Preparing 1-oxygen-fluoro-2,3,5-trioxybenzoyl-L-ribose comprises (1) preparing solid acid catalyst phthalimide-N-sulfonic acid (PISA)/Gu-O-GN, taking L-ribose as raw material, obtaining 1-oxy-methyl-L-ribofuranose by methylation, and subjecting 1-oxo-methyl-L-ribofuranose to benzoylation reaction to obtain 1-oxo-methyl-2,3,5-trioxybenzoyl-L-ribofuranose, (3) preparing the product obtained in the step (2) by acetylation in the presence of solid acid PISA/Gu-O-GN to obtain 1-oxy-acetyl-2,3,5-trioxybenzoyl-β-L-ribofuranose, intermittently shaking the reaction solution by ultrasonic waves during the reaction, and preparing 1-oxo-2,3,5-trioxybenzoyl-β-L-ribofuranose by deacetylation, and (4) preparing 1-oxo-4-fluoro-2,3,5-trioxybenzoyl-L-ribofuranose from the product obtained in the step (3) through fluorination reaction. USE - The method is useful for preparing 1-oxygen-fluoro-2,3,5-trioxybenzoyl-L-ribose. ADVANTAGE - The method: increases the catalytic rate to 95.8%; and increases the catalytic rate by 20-50% compared with the existing liquid acid catalyst and solid acid catalyst.