▎ 摘　　要

NOVELTY - Graphene-combined treatment of cancer involves mixing and stirring a functionalized graphene oxide and hyaluronic acid, coating on a surface of a carrier by electrostatic attraction, centrifuging, washing, targeting tumor to the nano-transport carrier for controlled release of drug by photothermal response, taking 3 mg anticancer drug dissolved in 0.3 mL ultrapure water, dripping bovine serum protein solution and nano-transport carrier to prepare an intravenous preparation, giving the intravenous preparation to patient after 12 hours of observation, providing oxygen-reduced stored red blood cells to patient, heating in the active portion of cancer cells by infrared radiation, exposing the patient to light, loading a graphene-based material on graphene, separating electrons and holes using graphene's high conductivity, and combining with a photothermal conversion of graphene to achieve photothermal therapy and sound photodynamic therapy to enhance the anti-cancer effect. USE - Graphene-combined treatment of cancer e.g. malignant tumor. DETAILED DESCRIPTION - Graphene-combined treatment of cancer involves preparing compound nano-drug loaded with an anti-cancer drug by performing hydrophobic-hydrophobic interaction between a hydrophobic surface of graphene and fat-soluble molecules and connecting hydrophilic molecules to the edges through electrostatic interaction or hydrogen bonding, coating graphene on a surface of the nanoparticles to form a core-shell structure, embedding graphene into the polymer to form a composite structure with pi - pi bonds or hydrogen bonds, dissolving the composite structure in 2 mL ultrapure water, maintaining in an ice bath for 4 minutes, stirring at room temperature for 24 hours, centrifuging at 2500 rpm for 5 minutes, taking the supernatant and dialyzing in a dialysis bag having a molecular weight cut-off of 1000 Da for 8 hours, and freeze-drying the product to obtain a functionalized graphene oxide, mixing and stirring the functionalized graphene oxide and hyaluronic acid at a mass ratio of 1:3 for 36 hours, coating the hyaluronic acid on a surface of the carrier by electrostatic attraction, centrifuging, washing, targeting tumor to the nano-transport carrier for controlled release of drug by photothermal response, taking 3 mg anticancer drug dissolved in 0.3 mL ultrapure water, dripping bovine serum protein solution and nano-transport carrier, stirring overnight at room temperature to obtain a combined drug delivery system, transferring to 5 mL centrifuge tube, centrifuging at 10 degrees C and 10000 rpm for 5 minutes, pouring the supernatant, adding 2-3 mL high-purity water, ultrasonically processing for 15 minutes, continually centrifuging, washing for four times, transferring to a watch glass, drying under vacuum at 50 degrees C, and ultrasonically dispersing in water to prepare an intravenous preparation, giving the intravenous preparation to patient after 12 hours of observation, providing oxygen-reduced stored red blood cells to patient, heating in the active portion of cancer cells by infrared radiation through a graphene heating element, making the body temperature reach 41.5-43 degrees C in a short time, exposing the patient to light of a predetermined intensity and wavelength, loading a graphene-based material on graphene, separating electrons and holes using graphene's high conductivity, and combining with a photothermal conversion of graphene under a laser having a wavelength of 808 nm to achieve photothermal therapy and sound photodynamic therapy to enhance the anti-cancer effect.