▎ 摘　　要

NOVELTY - Integrated circuit comprises (a) (i) substrate, (ii) an array of graphene field effect transistors arranged on the substrate, and (iii) chemically-sensitive bead provided in one or more wells of the array of graphene field effect transistors, each chemically-sensitive bead being configured with one or more reactants to interact with portions of strands of nucleic acids such that associated graphene field effect transistor detects change in ion concentration of reactants by a change in current flow from source to drain through an activation of graphene layer. USE - The integrated circuit is useful for performing sequencing reaction by sequencing of strands of nucleic acids (claimed). The integrated circuit is also used for analyzing biological and/or chemical materials e.g. nucleic acid, and genomics and/or bioinformatics analysis. ADVANTAGE - The integrated circuit enables to perform sequencing reaction in a cost-effective manner. DETAILED DESCRIPTION - Integrated circuit comprises (a) (i) substrate, (ii) an array of graphene field effect transistors arranged on the substrate, each of the graphene field effect transistors comprising (1) a primary layer forming a base layer, (2) a secondary layer over the primary layer, the secondary layer being formed of a first nonconductive material and comprising a source and a drain formed in the first nonconductive material, the source and drain being separated one from the other by a channel, and the source and drain being formed of an electrically conductive material, and (3) tertiary layer over the secondary layer, where the tertiary layer comprises gate formed over channel to electrically connect source and the drain, the gate being formed of a graphene layer, and further comprises surface structure that overlaps source and drain in the secondary layer, the surface structure further defining a well having side walls and bottom that extends over at least portion of graphene layer of gate so as to form a reaction chamber for performance of sequencing reaction, and (iii) chemically-sensitive bead provided in one or more wells of the array of graphene field effect transistors, each chemically-sensitive bead being configured with one or more reactants to interact with portions of the strands of nucleic acids such that the associated graphene field effect transistor detects a change in ion concentration of the reactants by a change in current flow from the source to the drain through an activation of the graphene layer, (b) (i) substrate, and (ii) above-mentioned array of graphene field effect transistors arranged on substrate, where one or more of graphene field effect transistors of integrated circuit is configured for detecting a change in ion concentration by change in current flow from source to drain through an activation of graphene layer resulting from performance of the sequencing reaction, or (c) (i) substrate, (ii) an array of graphene field effect transistors arranged on the substrate, each of the graphene field effect transistors comprising (1) primary layer forming a base layer, (2) an intermediary layer over the primary layer, the intermediary layer being formed of a first nonconductive material and comprising a source and a drain formed in the first nonconductive material, the source and drain being separated from each other by a channel, and source and drain being formed of electrically conductive material, and (3) above-mentioned tertiary layer over secondary layer.