• 专利标题:   Preparation of copper monosulfide-loaded graphene nanoscroll nanomaterials in antitumor photothermal therapy agent, by adding chloroauric acid to 4-hydroxyethyl piperazine ethanesulfonic acid solution, reacting, adding hyaluronic acid and sodium sulfide nonahydrate to react, centrifuging and drying.
  • 专利号:   CN115137819-A
  • 发明人:   LIU F, YAN G, MA X, FAN J, CHEN S
  • 专利权人:   WUHAN INST TECHNOLOGY
  • 国际专利分类:   A61K041/00, A61K009/14, A61P035/00, B82Y020/00, B82Y030/00, B82Y040/00, B82Y005/00
  • 专利详细信息:   CN115137819-A 04 Oct 2022 A61K-041/00 202200 Chinese
  • 申请详细信息:   CN115137819-A CN10579326 25 May 2022
  • 优先权号:   CN10579326

▎ 摘  要

NOVELTY - Preparation method of copper monosulfide-loaded graphene nanoscroll (GNS) nanomaterial in a virus-like shape involves (S1) using an aqueous phase synthesis method, adding a chloroauric acid methanol solution to a 4-hydroxyethyl piperazine ethanesulfonic acid solution and leaving until the color of the solution becomes blue-green to obtain a gold nanostar solution with the particle size of 40-50 nm, (S2) using the aqueous phase synthesis method, adding hyaluronic acid to the gold nanostar solution, adding copper(II) chloride dihydrate, stirring and heating at 95℃, adding sodium sulfide nonahydrate and stirring until the color of the solution changes to dark green to obtain a crude product solution of the GNS nanomaterial solution loaded with copper monosulfide in the virus-like shape and (S3) centrifuging, cleaning and drying the rough GNS nanomaterial solution loaded with copper monosulfide, where the particle size of the copper monosulfide-loaded GNS nanomaterial is 60-80 nm. USE - The method is used for preparing copper monosulfide-loaded GNS nanomaterials, which is used in preparing an antitumor photothermal therapy agent (all claimed). ADVANTAGE - The method is simple, controllable and environmentally friendly, and the prepared virus-like shape nanomaterials have excellent photothermal conversion performance and efficient tumor cell inhibition ability.