• 专利标题:   Nanoenzyme cascade bioreactor used medicament for treatment of tumor, is compound obtained by connecting substance A to surface of substance B, where carbon dot nanoenzyme is graphene quantum dot nanoenzyme, and substance B is exosome.
  • 专利号:   CN113930335-A, CN113930335-B
  • 发明人:   NIE G, ZHANG J, WANG X, DING H
  • 专利权人:   SHENZHEN SECOND PEOPLES HOSPITAL, SHENZHEN FUTIAN SECOND PEOPLE HOSPITAL
  • 国际专利分类:   A61K047/52, A61K047/68, A61K047/69, A61P035/00, C12M001/40
  • 专利详细信息:   CN113930335-A 14 Jan 2022 C12M-001/40 202256 Chinese
  • 申请详细信息:   CN113930335-A CN11544120 17 Dec 2021
  • 优先权号:   CN11544120

▎ 摘  要

NOVELTY - Nanoenzyme cascade bioreactor is a compound obtained by connecting a substance A to the surface of a substance B. The substance A is carbon dot nanoenzyme coupled with hypoxic inhibitor. The substance B is an exosome. USE - Nanoenzyme cascade bioreactor used medicament for treatment of tumor. ADVANTAGE - The nanoenzyme cascade bioreactor has carbon dot nanoenzyme, which is modified by utilizing exosome in a bionic manner, so that the enrichment capacity of tumor tissues is improved, natural NADPH oxidase 2 on the surface of the exosome is used for providing more catalytic substrates for the carbon dot nanoenzyme, efaproxiral (RSR13) is used to improve tumor tissue hypoxia, providing more oxygen for NADPH oxidase 2, and realize the synergistic linkage and synergism to inhibit the growth of the tumor. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: Method of preparing nanoenzyme cascade bioreactor, which involves: (1) coupling a hypoxic inhibitor on the surface of the carbon-point nano enzyme to obtain carbon-point nano enzyme coupled with the hypoxic inhibitor; (2) connecting a CD63 antibody to the free carboxyl on the surface of the carbon-point nanoenzyme coupled with the hypoxic inhibitor to obtain the carbon-point nanoenzyme coupled with the CD63 antibody and the hypoxic inhibitor; and (3) connecting the carbon dot nanoenzyme coupled with the CD63 antibody and the hypoxic inhibitor on the surface of the exosome to obtain the nanoenzyme cascade bioreactor. Medicament for treating tumor, which comprises the nanoenzyme cascade bioreactor.