• 专利标题:   Composite hydrogel for replacing and repairing temporomandibular joint, comprises water, polyvinyl alcohol, and chemically grafted or modified graphene oxide-polyurethane aqueous emulsion.
  • 专利号:   CN112972775-A, CN112972775-B
  • 发明人:   ZHU S, HOU Y, ZHANG L, JIN M, JIANG N, BI R, CAO P
  • 专利权人:   UNIV SICHUAN
  • 国际专利分类:   A61L027/44, A61L027/52, A61L027/54, C08J003/075, C08L029/04, C08L075/04
  • 专利详细信息:   CN112972775-A 18 Jun 2021 A61L-027/52 202167 Pages: 18 Chinese
  • 申请详细信息:   CN112972775-A CN10252714 09 Mar 2021
  • 优先权号:   CN10252714

▎ 摘  要

NOVELTY - Composite hydrogel comprises water, polyvinyl alcohol, and chemically grafted/modified graphene oxide-polyurethane aqueous emulsion. The water content in composite hydrogel is 70-85 wt.%, and mass ratio of graphene oxide-polyurethane and polyvinyl alcohol is 5:1-1:1. USE - Composite hydrogel for replacing/repairing temporomandibular joint (claimed). ADVANTAGE - The composite hydrogel has good biocompatibility, structural stability, and mechanical and lubricating property similar to natural joint disc. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing a composite hydrogel, which involves: (A) mixing polyvinyl alcohol and chemically grafted/modified graphene oxide-polyurethane aqueous emulsion with water, heating and stirring it to obtain a hydrogel precursor; and (B) introducing hydrogel precursor into a mold, and obtaining composite hydrogel by cross-linking through a freezing-thawing cycle method.