▎ 摘　　要

NOVELTY - The method involves cleaning an amino acid oxidase template by using diluted hydrochloric acid. A silicon substrate is obtained. Holes are formed on the amino acid oxidase template. Amino acid oxidase template removing process is performed. The amino acid oxidase template is arranged into a vacuum drying box. A regular arrangement of a noble metal nano-rod array is obtained. Graphene mechanical peeling process is performed. Noble metal nanometer rod array and ion beam bombarding process is performed to remove a noble metal/graphene surface enhanced raman specroscopy substrate. USE - Noble metal/graphene SERS substrate manufacturing method. ADVANTAGE - The method enables improving hotspot uniformity, surface enhanced raman specroscopy qualitative and quantitative analysis efficiency and surface enhanced raman specroscopy signal repeatability and stability. DESCRIPTION OF DRAWING(S) - The drawing shows a photographic view of a noble metal/graphene surface enhanced raman specroscopy substrate.