▎ 摘　　要

NOVELTY - An apparatus comprises a membrane that defines first and second chambers, a first set of electrodes disposed in the first and second chambers respectively and configured to generate a first electric field in a conducting media between the first and second chambers, a first current detector configured to measure a first current between the first set of electrodes, a second set of electrodes electrically contacting the membrane and configured to generate a second electric field across the pore of the membrane, a second current detector configured to measure a second current between the second set of electrodes, a plasmonic feature disposed on the membrane adjacent to the pore, a light source configured to emit light onto the plasmonic feature, a light collector configured to collect the light scattered from the plasmonic feature, and at least one computing device. USE - Apparatus for identifying molecules used for detecting a molecule attribute, where the molecule is a nucleic acid comprising DNA or RNA, the molecule attribute is a size of the molecule or sequence of the nucleic acid (all claimed). ADVANTAGE - The apparatus utilizes multi-modal nanopore sequencing that uses trans-membrane and trans-channel field effect electrical signals for e.g., conductance, inductance, capacitance, eddy current, induced electric and magnetic fields (EMF), magnetism, or other suitable electrical modalities and surface plasmon resonance, improves a nanopore sequencing that uses a single-modality of measurement of trans-membrane electrical signal, a single-modal nanopore sequencing relies on insulating thin films, which limits spatial-temporary accuracy and throughput, provides accuracy and repeatability for sequencing fidelity for timely epidemiological contact tracing, mutation monitoring, and therapeutic and vaccine development, provides cross-validation between the signals, which can improve accuracy and increase translocation/read rate or throughput. DETAILED DESCRIPTION - An apparatus comprises a membrane that defines first and second chambers, a first set of electrodes disposed in the first and second chambers respectively and configured to generate a first electric field in a conducting media between the first and second chambers, a first current detector configured to measure a first current between the first set of electrodes, a second set of electrodes electrically contacting the membrane and configured to generate a second electric field across the pore of the membrane, a second current detector configured to measure a second current between the second set of electrodes, a plasmonic feature disposed on the membrane adjacent to the pore, a light source configured to emit light onto the plasmonic feature, a light collector configured to collect the light scattered from the plasmonic feature, and at least one computing device configured to identify at least one attribute of the molecule that passes through the pore of the membrane based on at least one of the first current, the second current, and the scattered light, where the membrane including a pore that permits a molecule to pass through and move between the first and second chambers. An INDEPENDENT CLAIM is included for a method for detecting a molecule attribute, which involves providing an apparatus for identifying molecules, measuring at least one of a first signal representative of a first electric current or voltage supplying between the first set of electrodes, a second signal representative of a second electric current or voltage supplying between the second set of electrodes, or a third signal representative of a light scattered from the plasmonic feature deposited near the pore, and determining a molecule attribute based on the at least one of the first signal, the second signal, or the third signal. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of multi-modal nanopore sequencing system. 106membrane 107Pore 111conductive electrodes 115Second electrical measurement device 124Collect light