• 专利标题:   Polyethylene glycol (PEG)-folate-mediated doxorubicin loaded graphene oxide nanoparticles obtained using PEG-mediated folate graphene oxide, and stirring PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticles.
  • 专利号:   CN103784407-A, CN103784407-B
  • 发明人:   JI H, TANG J, WU L, DAN S, SHI S, ZHUANG Y
  • 专利权人:   UNIV HARBIN MEDICAL
  • 国际专利分类:   A61K031/704, A61K047/34, A61K009/14, A61P035/00
  • 专利详细信息:   CN103784407-A 14 May 2014 A61K-009/14 201446 Pages: 8 Chinese
  • 申请详细信息:   CN103784407-A CN10066632 26 Feb 2014
  • 优先权号:   CN10066632

▎ 摘  要

NOVELTY - Polyethylene glycol (PEG)-folate-mediated doxorubicin loaded graphene oxide nanoparticles obtained using PEG-mediated folate graphene oxide as carrier material, and magnetically stirring PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticles, where mass ratio of doxorubicin to carrier material is 1-5:1. USE - The PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticles are useful for preparing anti-tumor medicine (claimed). ADVANTAGE - The PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticles reduces side effects and toxicity, increases quantity of nnaopartcile, improves medicine targeting and prolongs plasma half-life, average residence time and detension time. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for preparing the PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticles which involves dissolving doxorubicin, using phosphate buffered solution of pH 7, magnetically stirring at 300-1000 rotations per minute (rpm) and low temperature for 12-48 hours, filtering using high molecule super filter membrane, collecting filter cake and filtrate, where the filter cake is PEG-folate-mediated doxorubicin loaded graphene oxide nanoparticle.